Omadacycline Injection

51 interactions 25 cited references
Also sold as: Nuzyra Nuzyra®
About Omadacycline Injection

Omadacycline injection is used to treat infections caused by bacteria, including pneumonia and certain infections of the skin. Omadacycline injection is in a class of medications called tetracycline antibiotics. It works by preventing the growth and spread of bacteria. Antibiotics such as omadacycline will not work for… Read the full Omadacycline Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Acenocoumarol Apixaban Ardeparin Argatroban Betrixaban
1 Contraindicated 34 Major 16 Moderate
All (51) Contraindicated (1) Major (34) Moderate (16)

Contraindicated

Omadacycline Injection Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Omadacycline Injection Acenocoumarol Increased risk of bleeding Details Omadacycline Injection Apixaban Eliquis Increased risk of bleeding Details Omadacycline Injection Ardeparin Increased risk of bleeding Details Omadacycline Injection Argatroban Increased risk of bleeding Details Omadacycline Injection Betrixaban Bevyxxa® Increased risk of bleeding Details Omadacycline Injection Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Injection Bivalirudin Angiomax Increased risk of bleeding Details Omadacycline Injection Certoparin Increased risk of bleeding Details Omadacycline Injection Dabigatran Etexilate Increased risk of bleeding Details Omadacycline Injection Dalteparin Fragmin Increased risk of bleeding Details Omadacycline Injection Danaparoid Increased risk of bleeding Details Omadacycline Injection Desirudin Iprivask Increased risk of bleeding Details Omadacycline Injection Edoxaban Savaysa Increased risk of bleeding Details Omadacycline Injection Enoxaparin Lovenox Increased risk of bleeding Details Omadacycline Injection Ethinyl Estradiol Reduced ethinyl estradiol exposure, reduced efficacy of ethinyl estradiol and an increased risk of breakthrough bleeding and/or co... Details Omadacycline Injection Etretinate An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Injection Fondaparinux Arixtra Increased risk of bleeding Details Omadacycline Injection Heparin Increased risk of bleeding Details Omadacycline Injection Isotretinoin Absorica An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Injection Lepirudin Increased risk of bleeding Details Omadacycline Injection Levonorgestrel After banger Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Omadacycline Injection Magnesium Sulfate May reduce absorption of tetracycline antibiotics Details Omadacycline Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Omadacycline Injection Palovarotene Sohonos Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Omadacycline Injection Parnaparin Increased risk of bleeding Details Omadacycline Injection Phenindione Increased risk of bleeding Details Omadacycline Injection Phenprocoumon Increased risk of bleeding Details Omadacycline Injection Porfimer Excessive intracellular damage in photosensitized tissues Details Omadacycline Injection Protein C Ceprotin Increased risk of bleeding Details Omadacycline Injection Reviparin Increased risk of bleeding Details Omadacycline Injection Rivaroxaban Xarelto Increased risk of bleeding Details Omadacycline Injection Tinzaparin Increased risk of bleeding Details Omadacycline Injection Tretinoin Altreno An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Omadacycline Injection Warfarin Coumadin Increased risk of bleeding Details

Moderate

Omadacycline Injection Aluminum Carbonate, Basic Decreased effectiveness of omadacycline Details Omadacycline Injection Aluminum Hydroxide AlternaGEL® Decreased effectiveness of omadacycline Details Omadacycline Injection Aluminum Phosphate Decreased effectiveness of omadacycline Details Omadacycline Injection Bismuth Subsalicylate Bismarex Decreased effectiveness of omadacycline Details Omadacycline Injection Calcium Decreased effectiveness of omadacycline Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.