Opium

29 interactions 3 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Midazolam Nasal Spray Granisetron Injection Palonosetron Injection Diazepam Rectal Diazepam Nasal Spray Morphine Injection

27 Major 2 Moderate

All (29) Major (27) Moderate (2)

Major

Opium Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Sertraline Explained An increased risk of serotonin syndrome Details Opium Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Opium Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Opium Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Opium Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Opium Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Opium Clopidogrel Plavix Reduced efficacy of clopidogrel Details Opium Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Opium Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Opium Esketamine Nasal Spray Spravato Increased risk of sedation Details Opium Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Opium Granisetron Injection Granisol Increased risk of serotonin syndrome Details Opium Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Lacosamide Injection Motpoly An increased risk of CNS depression Details Opium Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Opium Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Opium Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Opium Metoclopramide Injection Gimoti Increased risk of CNS depression Details Opium Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Opium Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Opium Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Opium Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Opium Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Opium Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Opium Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.