Opium Alkaloids
29 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Morphine Injection
Midazolam Nasal Spray
Buprenorphine
Diazepam Nasal Spray
Granisetron Injection
Midazolam Injection
Major
Opium Alkaloids Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Alkaloids Sertraline Explained An increased risk of serotonin syndrome Details Opium Alkaloids Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Opium Alkaloids Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Opium Alkaloids Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Opium Alkaloids Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Opium Alkaloids Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Opium Alkaloids Clopidogrel Plavix Reduced efficacy of clopidogrel Details Opium Alkaloids Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Opium Alkaloids Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Opium Alkaloids Esketamine Nasal Spray Spravato Increased risk of sedation Details Opium Alkaloids Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Alkaloids Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Opium Alkaloids Granisetron Injection Granisol Increased risk of serotonin syndrome Details Opium Alkaloids Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Alkaloids Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Alkaloids Lacosamide Injection Motpoly An increased risk of CNS depression Details Opium Alkaloids Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Opium Alkaloids Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Opium Alkaloids Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Opium Alkaloids Metoclopramide Injection Gimoti Increased risk of CNS depression Details Opium Alkaloids Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Opium Alkaloids Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Opium Alkaloids Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Opium Alkaloids Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Opium Alkaloids Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Opium Alkaloids Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsModerate
Opium Alkaloids Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Opium Alkaloids Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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