Orforglipron

16 interactions 1 explained in plain English
Also sold as: Foundayo
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levonorgestrel Intrauterine System Insulin Glulisine (Rdna Origin) Injection Ketoconazole Topical Levonorgestrel Nafcillin Injection Nateglinide
16 Major
All (16) Major (16)

Major

Orforglipron Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of simvastatin-related adverse reactions Details Orforglipron Encorafenib Braftovi Reduced orforglipron exposure and reduced efficacy of orforglipron Details Orforglipron Estradiol Delestrogen Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Orforglipron Estradiol Topical Divigel Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Orforglipron Estradiol Transdermal Patch Alora® Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Orforglipron Glimepiride Amaryl An increased risk of hypoglycemia Details Orforglipron Glipizide Glucotrol An increased risk of hypoglycemia Details Orforglipron Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Orforglipron Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Orforglipron Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details Orforglipron Ketoconazole Topical Extina® Foam Increased orforglipron exposure and an increased risk of orforglipron-related adverse reactions Details Orforglipron Levonorgestrel After banger Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Orforglipron Levonorgestrel Intrauterine System Kyleena Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Orforglipron Mitapivat Aqvesme Reduced orforglipron exposure and reduced efficacy of orforglipron Details Orforglipron Nafcillin Injection Unipen® Injection Reduced orforglipron exposure and reduced efficacy of orforglipron Details Orforglipron Nateglinide Starlix® An increased risk of hypoglycemia Details

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