Osilodrostat

70 interactions 5 explained in plain English
Also sold as: Isturisa
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Metronidazole Vaginal Granisetron Injection Encorafenib Buprenorphine Octreotide
1 Contraindicated 66 Major 3 Moderate
All (70) Contraindicated (1) Major (66) Moderate (3)

Contraindicated

Osilodrostat Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details

Major

Osilodrostat Abametapir Explained Increased exposure of CYP3A4 substrate Details Osilodrostat Amitriptyline Elavil Explained Increased risk of QT interval prolongation Details Osilodrostat Sertraline Explained Increased risk of QT interval prolongation Details Osilodrostat Buprenorphine Belbuca Explained Increased risk of QT interval prolongation Details Osilodrostat Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Osilodrostat Amisulpride Injection Barhemsys Increased risk of QT interval prolongation Details Osilodrostat Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Osilodrostat Aripiprazole Injection Abilify Increased risk of QT interval prolongation Details Osilodrostat Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Osilodrostat Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Osilodrostat Azithromycin AzaSite Increased risk of QT interval prolongation Details Osilodrostat Alfuzosin UroXatral Increased risk of QT interval prolongation Details Osilodrostat Anagrelide Agrylin Increased risk of QT interval prolongation Details Osilodrostat Bedaquiline Sirturo Increased risk of QT interval prolongation Details Osilodrostat Chloroquine Aralen® Increased risk of QT interval prolongation Details Osilodrostat Dasatinib Phyrago Increased risk of QT interval prolongation Details Osilodrostat Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Osilodrostat Deutetrabenazine Austedo Increased risk of QT interval prolongation Details Osilodrostat Disopyramide Norpace Increased risk of QT interval prolongation Details Osilodrostat Dofetilide Tikosyn Increased risk of QT interval prolongation Details Osilodrostat Dolasetron Anzemet Increased risk of QT interval prolongation Details Osilodrostat Dolasetron Injection Anzemet Increased risk of QT interval prolongation Details Osilodrostat Encorafenib Braftovi Increased risk of QT interval prolongation Details Osilodrostat Entrectinib Rozlytrek Increased risk of QT interval prolongation Details Osilodrostat Eribulin Injection Halaven Increased risk of QT interval prolongation Details Osilodrostat Famotidine Calmicid Increased risk of QT interval prolongation Details Osilodrostat Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Osilodrostat Felbamate Felbatol Increased risk of QT interval prolongation Details Osilodrostat Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Osilodrostat Flecainide Tambocor® Increased risk of QT interval prolongation Details Osilodrostat Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Osilodrostat Fostemsavir Rukobia Increased risk of torsade de pointes Details Osilodrostat Galantamine Razadyne Increased risk of QT interval prolongation Details Osilodrostat Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation Details Osilodrostat Gemifloxacin Factive Increased risk of QT interval prolongation Details Osilodrostat Glasdegib Daurismo Increased risk of QT interval prolongation Details Osilodrostat Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Osilodrostat Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation Details Osilodrostat Granisetron Injection Granisol Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.