Osimertinib
73 interactions 5 explained in plain English
Also sold as:
Tagrisso
Tagrisso®
About Osimertinib
Osimertinib is a kinase inhibitor used to treat certain types of non-small-cell lung cancer that has spread or to prevent it from returning after surgery. Read the full Osimertinib drug information page →
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jun 30, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Colchicine
Morphine Injection
Oxaliplatin Injection
Buprenorphine
Encorafenib
Octreotide
Contraindicated
Osimertinib Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity DetailsMajor
Osimertinib Amitriptyline Elavil Explained Increased risk of QT interval prolongation Details Osimertinib Sertraline Explained Increased risk of QT interval prolongation Details Osimertinib Buprenorphine Belbuca Explained Increased risk of QT interval prolongation Details Osimertinib Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Osimertinib Alpelisib Piqray Increased alpelisib exposure and an increased risk of alpelisib-related adverse effects and toxicity Details Osimertinib Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Osimertinib Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Osimertinib Aripiprazole Injection Abilify Increased risk of QT interval prolongation Details Osimertinib Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Osimertinib Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Osimertinib Azithromycin AzaSite Increased risk of QT interval prolongation Details Osimertinib Alfuzosin UroXatral Increased risk of QT interval prolongation Details Osimertinib Anagrelide Agrylin Increased risk of QT interval prolongation Details Osimertinib Bedaquiline Sirturo Increased risk of QT interval prolongation Details Osimertinib Chloroquine Aralen® Increased risk of QT interval prolongation Details Osimertinib Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Osimertinib Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Osimertinib Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Osimertinib Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Osimertinib Dasatinib Phyrago Increased risk of QT interval prolongation Details Osimertinib Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Osimertinib Deutetrabenazine Austedo Increased risk of QT interval prolongation Details Osimertinib Digoxin Cardoxin® Increased digoxin exposure Details Osimertinib Disopyramide Norpace Increased risk of QT interval prolongation Details Osimertinib Dofetilide Tikosyn Increased risk of QT interval prolongation Details Osimertinib Dolasetron Anzemet Increased risk of QT interval prolongation Details Osimertinib Dolasetron Injection Anzemet Increased risk of QT interval prolongation Details Osimertinib Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Osimertinib Encorafenib Braftovi Increased risk of QT interval prolongation Details Osimertinib Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Osimertinib Eribulin Injection Halaven Increased risk of QT interval prolongation Details Osimertinib Famotidine Calmicid Increased risk of QT interval prolongation Details Osimertinib Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Osimertinib Felbamate Felbatol Increased risk of QT interval prolongation Details Osimertinib Flecainide Tambocor® Increased risk of QT interval prolongation Details Osimertinib Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Osimertinib Fostemsavir Rukobia Increased risk of torsade de pointes Details Osimertinib Galantamine Razadyne Increased risk of QT interval prolongation Details Osimertinib Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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