Ospemifene

43 interactions 14 cited references
Also sold as: Osphena Osphena®
About Ospemifene

Ospemifene is used to treat changes due to menopause (''change of life,'' the end of monthly menstrual periods) in and around the vagina that can cause painful sexual intercourse and vaginal dryness. Ospemifene is in a class of medications called hormones. It works by replacing estrogen that is normally produced by the… Read the full Ospemifene drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Regorafenib Ketoconazole Topical Ketoconazole Fluvoxamine Fluconazole Ceritinib
12 Major 31 Moderate
All (43) Major (12) Moderate (31)

Major

Ospemifene Abiraterone Abirtega Increased ospemifene exposure and increased risk of adverse events Details Ospemifene Ketoconazole Topical Extina® Foam Increased ospemifene exposure Details Ospemifene Abiraterone Acetate Abirtega Increased ospemifene exposure and increased risk of adverse events Details Ospemifene Abiraterone Acetate, Micronized Abirtega Increased ospemifene exposure and increased risk of adverse events Details Ospemifene Amiodarone Nexterone Increased ospemifene exposure and increased risk of adverse events Details Ospemifene Ceritinib Zykadia Increased exposure of CYP3A and CYP2C9 substrate Details Ospemifene Eslicarbazepine Acetate Aptiom Altered CYP3A4/CYP2C19 substrate exposure Details Ospemifene Fluconazole Diflucan Increased ospemifene exposure Details Ospemifene Fluvoxamine Increased ospemifene exposure and increased risk of adverse events Details Ospemifene Ketoconazole Extina Increased ospemifene exposure Details Ospemifene Piperaquine Increased exposure of piperaquine and CYP3A4 substrates Details Ospemifene Regorafenib Stivarga Increased ospemifene exposure and increased risk of adverse events Details

Moderate

Ospemifene Dexamethasone Injection Decadron Decreased ospemifene exposure and efficacy Details Ospemifene Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased ospemifene exposure and efficacy Details Ospemifene Nafcillin Injection Unipen® Injection Decreased ospemifene exposure and efficacy Details Ospemifene Nevirapine Viramune Decreased ospemifene exposure and efficacy Details Ospemifene Amobarbital Amytal Decreased ospemifene exposure and efficacy Details Ospemifene Aprobarbital Decreased ospemifene exposure and efficacy Details Ospemifene Bosentan Decreased ospemifene exposure and efficacy Details Ospemifene Butabarbital Decreased ospemifene exposure and efficacy Details Ospemifene Butalbital Decreased ospemifene exposure and efficacy Details Ospemifene Carbamazepine Carbatrol Decreased ospemifene exposure and efficacy Details Ospemifene Dexamethasone Decreased ospemifene exposure and efficacy Details Ospemifene Efavirenz Decreased ospemifene exposure and efficacy Details Ospemifene Enzalutamide Xtandi Decreased ospemifene exposure and efficacy Details Ospemifene Etravirine Intelence Decreased ospemifene exposure and efficacy Details Ospemifene Fosphenytoin Cerebyx Decreased ospemifene exposure and efficacy Details Ospemifene Mephobarbital Decreased ospemifene exposure and efficacy Details Ospemifene Methohexital Brevital Decreased ospemifene exposure and efficacy Details Ospemifene Modafinil Provigil Decreased ospemifene exposure and efficacy Details Ospemifene Nafcillin Decreased ospemifene exposure and efficacy Details Ospemifene Oxcarbazepine Oxtellar Decreased ospemifene exposure and efficacy Details Ospemifene Pentobarbital Fatal-Plus Decreased ospemifene exposure and efficacy Details Ospemifene Phenobarbital Fidoquel Decreased ospemifene exposure and efficacy Details Ospemifene Phenytoin Dilantin Decreased ospemifene exposure and efficacy Details Ospemifene Prednisone Deltasone Decreased ospemifene exposure and efficacy Details Ospemifene Primidone Mysoline Decreased ospemifene exposure and efficacy Details Ospemifene Rifabutin Mycobutin Decreased ospemifene exposure and efficacy Details Ospemifene Rifampin Rifadin Decreased ospemifene exposure and efficacy Details Ospemifene Rifapentine Priftin Decreased ospemifene exposure and efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.