Oxaprozin

91 interactions 5 explained in plain English
Also sold as: Coxanto Daypro Daypro®
About Oxaprozin

Oxaprozin is a nonsteroidal anti-inflammatory medication used to relieve pain and swelling from arthritis. Read the full Oxaprozin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Epoprostenol Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Contraindicated

Oxaprozin Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Oxaprozin Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Oxaprozin Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Oxaprozin Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Oxaprozin Amitriptyline Elavil Explained An increased risk of bleeding Details Oxaprozin Sertraline Explained An increased risk of bleeding Details Oxaprozin Apixaban Eliquis Explained An increased risk of bleeding Details Oxaprozin Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Oxaprozin Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Oxaprozin Betrixaban Bevyxxa® An increased risk of bleeding Details Oxaprozin Anagrelide Agrylin An increased risk of bleeding Details Oxaprozin Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Oxaprozin Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Oxaprozin Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Oxaprozin Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Oxaprozin Clopidogrel Plavix An increased risk of bleeding Details Oxaprozin Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Oxaprozin Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Oxaprozin Dabigatran Pradaxa® An increased risk of bleeding Details Oxaprozin Dabigatran Etexilate An increased risk of bleeding Details Oxaprozin Dalteparin Injection Fragmin An increased risk of bleeding Details Oxaprozin Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Oxaprozin Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Oxaprozin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Oxaprozin Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Oxaprozin Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Oxaprozin Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Oxaprozin Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Oxaprozin Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Oxaprozin Dipyridamole Permole® An increased risk of bleeding Details Oxaprozin Edoxaban Savaysa An increased risk of bleeding Details Oxaprozin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Oxaprozin Enoxaparin Lovenox An increased risk of bleeding Details Oxaprozin Enoxaparin Injection Lovenox An increased risk of bleeding Details Oxaprozin Epoprostenol Flolan An increased risk of bleeding Details Oxaprozin Etodolac Lodine Increased risk of bleeding Details Oxaprozin Fenoprofen Fenopron Increased risk of bleeding Details Oxaprozin Flurbiprofen Ansaid Increased risk of bleeding Details Oxaprozin Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Oxaprozin Fondaparinux Arixtra An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.