Oxyphenbutazone

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Oxyphenbutazone Amitriptyline Elavil Explained An increased risk of bleeding Details Oxyphenbutazone Sertraline Explained An increased risk of bleeding Details Oxyphenbutazone Apixaban Eliquis Explained An increased risk of bleeding Details Oxyphenbutazone Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Oxyphenbutazone Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Oxyphenbutazone Betrixaban Bevyxxa® An increased risk of bleeding Details Oxyphenbutazone Anagrelide Agrylin An increased risk of bleeding Details Oxyphenbutazone Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Oxyphenbutazone Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Oxyphenbutazone Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Oxyphenbutazone Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Oxyphenbutazone Clopidogrel Plavix An increased risk of bleeding Details Oxyphenbutazone Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Oxyphenbutazone Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Oxyphenbutazone Dabigatran Pradaxa® An increased risk of bleeding Details Oxyphenbutazone Dabigatran Etexilate An increased risk of bleeding Details Oxyphenbutazone Dalteparin Injection Fragmin An increased risk of bleeding Details Oxyphenbutazone Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Oxyphenbutazone Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Oxyphenbutazone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Oxyphenbutazone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Oxyphenbutazone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Oxyphenbutazone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Oxyphenbutazone Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Oxyphenbutazone Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Oxyphenbutazone Dipyridamole Permole® An increased risk of bleeding Details Oxyphenbutazone Edoxaban Savaysa An increased risk of bleeding Details Oxyphenbutazone Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Oxyphenbutazone Enoxaparin Lovenox An increased risk of bleeding Details Oxyphenbutazone Enoxaparin Injection Lovenox An increased risk of bleeding Details Oxyphenbutazone Epoprostenol Flolan An increased risk of bleeding Details Oxyphenbutazone Etodolac Lodine Increased risk of bleeding Details Oxyphenbutazone Fenoprofen Fenopron Increased risk of bleeding Details Oxyphenbutazone Flurbiprofen Ansaid Increased risk of bleeding Details Oxyphenbutazone Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Oxyphenbutazone Fondaparinux Arixtra An increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.