Oxytetracycline

22 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Penicillin G Benzathine Injection Estradiol Topical Penicillin G Procaine Injection Penicillin V Potassium
1 Contraindicated 18 Major 3 Moderate
All (22) Contraindicated (1) Major (18) Moderate (3)

Contraindicated

Oxytetracycline Acitretin Soriatane® An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details

Major

Oxytetracycline Isotretinoin Absorica Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Oxytetracycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Oxytetracycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Oxytetracycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Oxytetracycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Oxytetracycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Oxytetracycline Digoxin Cardoxin® Increased digoxin levels and digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Oxytetracycline Estradiol Delestrogen Decreased contraceptive effectiveness Details Oxytetracycline Estradiol Topical Divigel Decreased contraceptive effectiveness Details Oxytetracycline Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Oxytetracycline Levonorgestrel After banger Decreased contraceptive effectiveness Details Oxytetracycline Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Oxytetracycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Oxytetracycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Oxytetracycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Oxytetracycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Oxytetracycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Oxytetracycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

Moderate

Oxytetracycline Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Oxytetracycline Lanthanum Fosrenol® Reduced bioavailability of tetracyclines Details Oxytetracycline Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.