Paclitaxel Protein-Bound

28 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Doxorubicin Capmatinib Ketoconazole Topical Irbesartan Clotrimazole Nevirapine
23 Major 5 Moderate
All (28) Major (23) Moderate (5)

Major

Paclitaxel Protein-Bound Abiraterone Abirtega Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Capmatinib Tabrecta Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Cisplatin Injection Platinol-AQ® Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Clopidogrel Plavix Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Clotrimazole Aardora Anti-Fungal Maximum Strength Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Clotrimazole Lozenge Mycelex® Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Clotrimazole Topical Cruex Antifungal Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Cyclosporine Injection Atopica Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Cyclosporine Ophthalmic Cequa Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Deferasirox Exjade Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Dexamethasone Injection Decadron Reduced PACLitaxel exposure Details Paclitaxel Protein-Bound Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced PACLitaxel exposure Details Paclitaxel Protein-Bound Doxorubicin Adriamycin Increase in exposure of DOXOrubicin and its metabolites Details Paclitaxel Protein-Bound Enasidenib Idhifa Altered (increased/reduced) PACLitaxel exposure and an increased risk of PACLitaxel-related adverse effects or reduced efficacy of... Details Paclitaxel Protein-Bound Gemfibrozil Lopid Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Idarubicin Idamycin Increased risk of cardiotoxicity Details Paclitaxel Protein-Bound Irbesartan Avapro Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Istradefylline Nourianz Increased PACLitaxel exposure Details Paclitaxel Protein-Bound Ketoconazole Topical Extina® Foam Increased PACLitaxel exposure and an increased risk of PACLitaxel-related adverse reactions Details Paclitaxel Protein-Bound Letermovir Injection Prevymis Increased PACLitaxel exposure and an increased risk of PACLitaxel-related adverse reactions Details Paclitaxel Protein-Bound Nafcillin Injection Unipen® Injection Reduced PACLitaxel exposure Details Paclitaxel Protein-Bound Nevirapine Viramune Reduced PACLitaxel exposure Details

Moderate

Paclitaxel Protein-Bound Simvastatin Flolipid Explained Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Paclitaxel Protein-Bound Felodipine Plendil® Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Paclitaxel Protein-Bound Lovastatin Altocor® Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Paclitaxel Protein-Bound Midazolam Nasal Spray Nayzilam Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details Paclitaxel Protein-Bound Midazolam Injection Nayzilam Altered (increased/reduced) PACLitaxel exposure, reduced PACLitaxel exposure and an increased PACLitaxel-related adverse reactions... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.