Papaverine

33 interactions 3 explained in plain English
Also sold as: Pavacot®
About Papaverine

Papaverine is used to improve blood flow in patients with circulation problems. It works by relaxing the blood vessels so that blood can flow more easily to the heart and through the body. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Papaverine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metronidazole Vaginal Buprenorphine Oxaliplatin Injection Histrelin Implant Ketoconazole Topical Inotuzumab Ozogamicin Injection
33 Major
All (33) Major (33)

Major

Papaverine Sertraline Explained An increased risk of QT interval prolongation Details Papaverine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Papaverine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Papaverine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Papaverine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Papaverine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Papaverine Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Papaverine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Papaverine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Papaverine Dasatinib Phyrago An increased risk of QT interval prolongation Details Papaverine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Papaverine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Papaverine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Papaverine Encorafenib Braftovi Increased risk of QT interval prolongation Details Papaverine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Papaverine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Papaverine Fostemsavir Rukobia Increased risk of torsade de pointes Details Papaverine Glasdegib Daurismo Increased risk of QT interval prolongation Details Papaverine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Papaverine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Papaverine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Papaverine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Papaverine Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation Details Papaverine Lefamulin Xenleta Increased risk of QT interval prolongation Details Papaverine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Papaverine Levodopa Oral Inhalation Inbrija Reduced efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delus... Details Papaverine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Papaverine Metronidazole Flagyl An increased risk of QT interval prolongation Details Papaverine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Papaverine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Papaverine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Papaverine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Papaverine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.