Paroxetine

Name: Paroxetine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

141 interactions 8 explained in plain English

Also sold as: Paxil

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Colchicine Granisetron Transdermal Patch Palonosetron Injection Etodolac Histrelin Implant

2 Contraindicated 134 Major 5 Moderate

All (141) Contraindicated (2) Major (134) Moderate (5)

Moderate

Paroxetine Trospium / Xanomeline Cobenfy Explained Increased xanomeline exposure and an increased risk on severity and frequency of xanomeline-related adverse reactions Details Paroxetine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Paroxetine Dihydroergotamine Injection DHE-45® Injection An increased risk of weakness, hyperreflexia and incoordination Details Paroxetine Dihydroergotamine Nasal Spray Migranal An increased risk of weakness, hyperreflexia and incoordination Details Paroxetine Lumateperone Caplyta An increased risk for serotonin reuptake inhibitor (SRI)-associated adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.