Peginterferon Alfa-2A Injection

31 interactions 173 cited references
Also sold as: Pegasys Pegasys®
About Peginterferon Alfa-2A Injection

Peginterferon alfa-2a is used alone or in combination with other medications to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in people who show signs of liver damage. Peginterferon alfa-2a is also used to treat chronic hepatitis B infection (swelling of the liver caused by a… Read the full Peginterferon Alfa-2A Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Bacillus Of Calmette And Guerin Vaccine, Live Measles Virus Vaccine, Live Fezolinetant
11 Contraindicated 18 Major 2 Moderate
All (31) Contraindicated (11) Major (18) Moderate (2)

Contraindicated

Peginterferon Alfa-2A Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Fezolinetant Increased fezolinetant exposure Details Peginterferon Alfa-2A Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Telbivudine Tyzeka® Increased risk of peripheral neuropathy Details Peginterferon Alfa-2A Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Peginterferon Alfa-2A Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Azathioprine Azasan An increased risk of hepatotoxicity Details Peginterferon Alfa-2A Injection Bendamustine Increased bendamustine exposure and an increased risk of bendamustine-related adverse effects Details Peginterferon Alfa-2A Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Clomipramine Anafranil Increased clomiPRAMINE exposure Details Peginterferon Alfa-2A Injection Clozapine Clozaril Increased clozapine exposure Details Peginterferon Alfa-2A Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Peginterferon Alfa-2A Injection Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Peginterferon Alfa-2A Injection Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Peginterferon Alfa-2A Injection Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Peginterferon Alfa-2A Injection Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details Peginterferon Alfa-2A Injection Theophylline Accurbron® Theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Peginterferon Alfa-2A Injection Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Peginterferon Alfa-2A Injection Triclabendazole Egaten Increased risk of QT interval prolongation Details Peginterferon Alfa-2A Injection Warfarin Coumadin Increased warfarin exposure and an increased INR Details

Moderate

Peginterferon Alfa-2A Injection Methadone Diskets Increased methadone concentrations Details Peginterferon Alfa-2A Injection Propranolol Hemangeol Increased propranolol exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.