Pegloticase Injection

Name: Pegloticase Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

4 interactions 29 cited references

Also sold as: Krystexxa Krystexxa®

About Pegloticase Injection

Pegloticase injection is used alone or in combination with methotrexate (Trexall, Xatmep) and folic acid to treat chronic gout (sudden, severe pain, redness, and swelling in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults who cannot take or did not respond to… Read the full Pegloticase Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Allopurinol Oxypurinol Probenecid Sulfinpyrazone

4 Major

All (4) Major (4)

Major

Pegloticase Injection Allopurinol Aloprim Increased risk of anaphylaxis and infusion reactions Details Pegloticase Injection Oxypurinol Increased risk of anaphylaxis and infusion reactions Details Pegloticase Injection Probenecid Increased risk of anaphylaxis and infusion reactions Details Pegloticase Injection Sulfinpyrazone Increased risk of anaphylaxis and infusion reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.