Pembrolizumab Injection

15 interactions 476 cited references
Also sold as: Keytruda Keytruda®
About Pembrolizumab Injection

Pembrolizumab injection is used alone or in combination with other chemotherapy medications to treat certain types of melanoma (a type of skin cancer), Merkel cell carcinoma (MCC; a type of skin cancer), and cutaneous squamous cell carcinoma (CSCC; skin cancer). It is also used to prevent the return of melanoma after s… Read the full Pembrolizumab Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Typhoid Vaccine Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Measles Virus Vaccine, Live Varicella Virus Vaccine, Live
9 Contraindicated 6 Major
All (15) Contraindicated (9) Major (6)

Contraindicated

Pembrolizumab Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Pembrolizumab Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Pembrolizumab Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Pembrolizumab Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Pembrolizumab Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pembrolizumab Injection Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.