Pemetrexed

25 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naproxen Ibuprofen Etodolac Diclofenac Ophthalmic Diclofenac Topical (Actinic Keratosis) Mefenamic Acid

25 Major

All (25) Major (25)

Major

Pemetrexed Aspirin Acuprin® Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Aspirin Rectal Aspirin Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Bromfenac Ophthalmic Bromday® Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Diclofenac Ophthalmic Voltaren® Eye Drops Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Diclofenac Topical (Actinic Keratosis) Pennsaid Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Diclofenac Topical (Arthritis Pain) Pennsaid® Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Diclofenac Transdermal Patch Flector Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Etodolac Lodine Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Fenoprofen Fenopron Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Flurbiprofen Ansaid Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Flurbiprofen Ophthalmic Ocufen Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Ibuprofen Addaprin Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Ketoprofen Actron® Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Ketorolac Acular Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Ketorolac Injection Acular Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Ketorolac Nasal Spray Sprix Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Ketorolac Ophthalmic Acular Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Meclofenamate Meclodium® Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Mefenamic Acid Ponstel® Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Meloxicam Alloxate Increased risk of PEMEtrexed-associated myelosuppression, renal toxicity, and gastrointestinal toxicity Details Pemetrexed Meloxicam Injection Alloxate Increased risk of PEMEtrexed-associated myelosuppression, renal toxicity, and gastrointestinal toxicity Details Pemetrexed Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Pemetrexed Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Pemetrexed Nabumetone Relafen Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Naproxen Aleve Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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