Pemetrexed Injection

80 interactions 421 cited references

Also sold as: Alimta Alimta® Axtle Pemfexy Pemfexy® Pemrydi Rtu

About Pemetrexed Injection

Pemetrexed injection is used in combination with other chemotherapy medications as a first treatment for a certain type of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. Pemetrexed injection is also used alone to treat NSCLC as ongoing treatment in people who have al… Read the full Pemetrexed Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Smallpox Monkeypox Vaccine Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live

9 Contraindicated 70 Major 1 Moderate

All (80) Contraindicated (9) Major (70) Moderate (1)

Contraindicated

Pemetrexed Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Pemetrexed Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Pemetrexed Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Pemetrexed Injection Aceclofenac Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Acemetacin Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Amtolmetin Guacil Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Aspirin Acuprin® Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Bromfenac Bromsite Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Bufexamac Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Celecoxib Celebrex Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Pemetrexed Injection Choline Salicylate Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Clonixin Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Dexibuprofen Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Dexketoprofen Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Diclofenac Aleve Arthritis Pain Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Diflunisal Dolobid Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Dipyrone Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Droxicam Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Pemetrexed Injection Etodolac Lodine Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Etofenamate Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Etoricoxib Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Felbinac Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Fenoprofen Fenopron Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Fepradinol Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Feprazone Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Floctafenine Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Flufenamic Acid Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Flurbiprofen Ansaid Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Ibuprofen Addaprin Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Pemetrexed Injection Indomethacin Indocin Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.