Pemetrexed Injection

Generic name: Pronounced as (pem'' e trex' ed)
Brand names
  • Alimta®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 04/15/2019

Pemetrexed injection is used in combination with other chemotherapy medications as a first treatment for a certain type of non-small cell lung cancer (NSCLC) that has spread to nearby tissues or to other parts of the body. Pemetrexed injection is also used alone to treat NSCLC as ongoing treatment in people who have already received certain chemotherapy medications and whose cancer has not worsened and in people who could not be treated successfully with other chemotherapy medications. Pemetrexed injection is also in combination with another chemotherapy medication as a first treatment for malignant pleural mesothelioma (a type of cancer that affects the inside lining of the chest cavity) in people who cannot be treated with surgery. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help cancer cells multiply.

Pemetrexed injection comes as a solution (liquid) to be injected into a vein over 10 minutes. Pemetrexed injection is administered by a doctor or nurse in a medical office or infusion center. It is usually given once every 21 days.

Your doctor will probably tell you to take other medications, such as folic acid (a vitamin), vitamin B12, and a corticosteroid such as dexamethasone to decrease some of the side effects of this medication. Your doctor will give you directions for taking these medications. Follow your doctor's directions carefully. Ask your doctor or pharmacist to explain any part you do not understand. If you miss a dose of one of these medications, call your doctor.

Your doctor will tell you to have regular blood tests before and during treatment with pemetrexed injection. Your doctor may change your dose of pemetrexed injection, delay treatment, or permanently stop your treatment based on the results of the blood tests.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before receiving pemetrexed injection,

  • tell your doctor and pharmacist if you are allergic to pemetrexed, mannitol (Osmitrol), any other medications, or any of the ingredients in pemetrexed injection. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention ibuprofen (Advil, Motrin). You should not take ibuprofen two days before, the day of, or for two days after you receive pemetrexed injection. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have had radiation therapy or have or have ever had kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. If you are female, you should use a reliable method of birth control while receiving pemetrexed injection and for at least 6 months after the final dose. If you are male, you and your female partner should use effective birth control while you are receiving pemetrexed injection and for 3 months after the final dose. If you or your partner becomes pregnant while using this medication, call your doctor. Pemetrexed injection may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with pemetrexed injection and for 1 week after the final dose.

  • you should know that pemetrexed injection may cause fertility problems in males that may affect your ability to father a child. It is not known if these effects are reversible. Talk to your doctor about the risks of receiving pemetrexed injection.

Unless your doctor tells you otherwise, continue your normal diet.

If you miss an appointment to receive a dose of pemetrexed injection, call your doctor as soon as possible.

  • Pemetrexed injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • nausea

    • vomiting

    • diarrhea

    • constipation

    • loss of appetite

    • weight loss

    • tiredness

    • difficulty falling asleep or staying asleep

    • joint pain

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment :

    • blisters, skin sores, skin peeling, or painful ulcers in your mouth, lips, nose, throat, or genital area

    • swelling, blistering, or rash that looks like a sunburn in an area previously treated with radiation

    • unusual bleeding or bruising

    • sore throat, fever, chills, cough or other signs of infection

    • chest pain

    • fast heartbeat

    • difficulty breathing or swallowing

    • slow or difficult speech

    • extreme tiredness or weakness

    • dizziness or faintness

    • weakness or numbness of an arm or leg

    • pain, burning, numbness, or tingling in the hands or feet

    • pale skin

    • headache

    • hives

    • itching

    • decreased urination

  • Pemetrexed injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to pemetrexed injection.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The metabolism of Pemetrexed can be decreased when combined with Moxifloxacin.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The metabolism of Pemetrexed can be increased when combined with Insulin glargine.
Leflunomide Leflunomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Pemetrexed.
Nevirapine Nevirapine The metabolism of Pemetrexed can be decreased when combined with Nevirapine.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Pemetrexed.
Anagrelide Anagrelide The metabolism of Pemetrexed can be decreased when combined with Anagrelide.
Cilostazol Cilostazol Cilostazol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Pemetrexed.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fenofibrate Fenofibrate Fenofibrate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Guanfacine Guanfacine Guanfacine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Mycophenolate Mycophenolate The risk or severity of adverse effects can be increased when Pemetrexed is combined with Mycophenolic acid.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Potassium Potassium Pemetrexed may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Prednisone Prednisone The risk or severity of adverse effects can be increased when Prednisone is combined with Pemetrexed.
Ranitidine Ranitidine Ranitidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Reserpine Reserpine Reserpine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Rizatriptan Rizatriptan Rizatriptan may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sumatriptan Sumatriptan Sumatriptan may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tacrolimus Tacrolimus Tacrolimus may increase the immunosuppressive activities of Pemetrexed.
Tizanidine Tizanidine The metabolism of Tizanidine can be decreased when combined with Pemetrexed.
Triamcinolone Triamcinolone The risk or severity of adverse effects can be increased when Triamcinolone is combined with Pemetrexed.
Zolmitriptan Zolmitriptan The metabolism of Pemetrexed can be decreased when combined with Zolmitriptan.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Famotidine Injection Famotidine Injection The excretion of Pemetrexed can be decreased when combined with Famotidine.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Pemetrexed.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Pemetrexed.
Levofloxacin Injection Levofloxacin Injection Levofloxacin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Meperidine Injection Meperidine Injection Meperidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Methylprednisolone Injection Methylprednisolone Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Methylprednisolone.
Metoclopramide Injection Metoclopramide Injection Metoclopramide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Vancomycin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Zidovudine Injection Zidovudine Injection The risk or severity of adverse effects can be increased when Zidovudine is combined with Pemetrexed.
Altretamine Altretamine Amphetamine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cyclosporine Cyclosporine Pemetrexed may increase the immunosuppressive activities of Cyclosporine.
Ondansetron Ondansetron The metabolism of Pemetrexed can be decreased when combined with Ondansetron.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Pemetrexed.
Torsemide Torsemide Torasemide may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The metabolism of Pemetrexed can be decreased when combined with Olanzapine.
Alosetron Alosetron The metabolism of Pemetrexed can be decreased when combined with Alosetron.
Hydroxychloroquine Hydroxychloroquine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Hydroxychloroquine.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Temozolomide Temozolomide The risk or severity of adverse effects can be increased when Pemetrexed is combined with Temozolomide.
Zaleplon Zaleplon Zaleplon may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Anakinra Anakinra The metabolism of Pemetrexed can be increased when combined with Anakinra.
Linezolid Linezolid The risk or severity of adverse effects can be increased when Linezolid is combined with Pemetrexed.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Pemetrexed.
Etanercept Injection Etanercept Injection The metabolism of Pemetrexed can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Pemetrexed can be increased when combined with Modafinil.
Perindopril Perindopril Perindopril may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sirolimus Sirolimus The risk or severity of adverse effects can be increased when Pemetrexed is combined with Sirolimus.
Epirubicin Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Pemetrexed.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Zonisamide Zonisamide Zonisamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Adalimumab Injection Adalimumab Injection The metabolism of Pemetrexed can be increased when combined with Adalimumab.
Atomoxetine Atomoxetine Atomoxetine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Glatiramer Injection Glatiramer Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Glatiramer.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Almotriptan Almotriptan Almotriptan may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Rosuvastatin Rosuvastatin The excretion of Pemetrexed can be decreased when combined with Rosuvastatin.
Emtricitabine Emtricitabine Pemetrexed may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection Interferon Beta-1a Subcutaneous Injection The metabolism of Pemetrexed can be decreased when combined with Interferon beta-1a.
Memantine Memantine Memantine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tegaserod Tegaserod The metabolism of Pemetrexed can be decreased when combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Frovatriptan Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Pemetrexed.
Gemifloxacin Gemifloxacin The metabolism of Pemetrexed can be decreased when combined with Gemifloxacin.
Darbepoetin Alfa Injection Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pemetrexed.
Infliximab Injection Infliximab Injection The metabolism of Pemetrexed can be increased when combined with Infliximab.
Duloxetine Duloxetine Duloxetine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tinidazole Tinidazole Tinidazole may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cinacalcet Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Pemetrexed.
Natalizumab Injection Natalizumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Natalizumab.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Erlotinib Erlotinib The metabolism of Pemetrexed can be decreased when combined with Erlotinib.
Eszopiclone Eszopiclone Eszopiclone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ganciclovir Ganciclovir Ganciclovir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Palifermin Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Pemetrexed.
Ribavirin Ribavirin Ribavirin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Valganciclovir Valganciclovir Valganciclovir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Entecavir Entecavir The metabolism of Pemetrexed can be decreased when combined with Entecavir.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Pemetrexed.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Pemetrexed can be increased when it is combined with Peginterferon alfa-2b.
Ramelteon Ramelteon Ramelteon may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fentanyl Fentanyl Pemetrexed may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Pregabalin Pregabalin Pregabalin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Deferasirox Deferasirox The serum concentration of Pemetrexed can be increased when it is combined with Deferasirox.
Phenylephrine Phenylephrine The metabolism of Pemetrexed can be increased when combined with Phenylephrine.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Abatacept Injection Abatacept Injection The metabolism of Pemetrexed can be increased when combined with Abatacept.
Rasagiline Rasagiline Rasagiline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Imatinib Imatinib The risk or severity of adverse effects can be increased when Imatinib is combined with Pemetrexed.
Sitagliptin Sitagliptin Sitagliptin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Varenicline Varenicline Varenicline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Bevacizumab Injection Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Pemetrexed.
Albuterol Albuterol Salbutamol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Paliperidone Paliperidone Paliperidone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Bortezomib Bortezomib The risk or severity of adverse effects can be increased when Bortezomib is combined with Pemetrexed.
Clofarabine Injection Clofarabine Injection The risk or severity of adverse effects can be increased when Clofarabine is combined with Pemetrexed.
Hepatitis B Vaccine Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Pemetrexed.
Influenza Vaccine, Inactivated or Recombinant Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Pemetrexed.
Influenza Vaccine, Live Intranasal Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Pemetrexed.
Live Shingles (Zoster) Vaccine (ZVL) Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Pemetrexed.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The metabolism of Pemetrexed can be increased when combined with Insulin glulisine.
Lubiprostone Lubiprostone Lubiprostone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of adverse effects can be increased when Oxaliplatin is combined with Pemetrexed.
Primaquine Primaquine The metabolism of Pemetrexed can be decreased when combined with Primaquine.
Rituximab Injection Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Pemetrexed.
Vorinostat Vorinostat The risk or severity of adverse effects can be increased when Pemetrexed is combined with Vorinostat.
Sorafenib Sorafenib The risk or severity of adverse effects can be increased when Sorafenib is combined with Pemetrexed.
Sunitinib Sunitinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Sunitinib.
Levocetirizine Levocetirizine Levocetirizine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pegaptanib Injection Pegaptanib Injection Pegaptanib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dasatinib Dasatinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Dasatinib.
Mexiletine Mexiletine The metabolism of Pemetrexed can be decreased when combined with Mexiletine.
Armodafinil Armodafinil The metabolism of Pemetrexed can be increased when combined with Armodafinil.
Azacitidine Injection Azacitidine Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Azacitidine.
Temsirolimus Temsirolimus The risk or severity of adverse effects can be increased when Pemetrexed is combined with Temsirolimus.
Nelarabine Injection Nelarabine Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Nelarabine.
Lenalidomide Lenalidomide The risk or severity of adverse effects can be increased when Lenalidomide is combined with Pemetrexed.
Nilotinib Nilotinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Nilotinib.
Bexarotene Bexarotene The risk or severity of adverse effects can be increased when Bexarotene is combined with Pemetrexed.
Budesonide Budesonide The risk or severity of adverse effects can be increased when Pemetrexed is combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of adverse effects can be increased when Chloramphenicol is combined with Pemetrexed.
Decitabine Injection Decitabine Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Decitabine.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Doripenem Injection Doripenem Injection Doripenem may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine Desvenlafaxine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Pemetrexed is combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Bendamustine.
Leucovorin Injection Leucovorin Injection The excretion of Pemetrexed can be decreased when combined with Leucovorin.
Flecainide Flecainide The metabolism of Flecainide can be decreased when combined with Pemetrexed.
Certolizumab Injection Certolizumab Injection The metabolism of Pemetrexed can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ixabepilone.
Irinotecan Injection Irinotecan Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Irinotecan.
Levoleucovorin Injection Levoleucovorin Injection The therapeutic efficacy of Pemetrexed can be decreased when used in combination with Levoleucovorin.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Estramustine Estramustine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Estramustine.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Pemetrexed.
Methylnaltrexone Injection Methylnaltrexone Injection Methylnaltrexone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Pemetrexed.
Midazolam Midazolam Midazolam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Pemetrexed.
Eltrombopag Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Pemetrexed.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Pemetrexed.
Milnacipran Milnacipran Milnacipran may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Plerixafor Injection Plerixafor Injection Plerixafor may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fesoterodine Fesoterodine Fesoterodine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Betaxolol Betaxolol The metabolism of Pemetrexed can be decreased when combined with Betaxolol.
Prasugrel Prasugrel Prasugrel may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Everolimus Everolimus The risk or severity of adverse effects can be increased when Pemetrexed is combined with Everolimus.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone The excretion of Pemetrexed can be decreased when combined with Dronedarone.
Pralatrexate Injection Pralatrexate Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Pralatrexate.
Palonosetron Injection Palonosetron Injection Palonosetron may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Saxagliptin Saxagliptin Saxagliptin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Telavancin Injection Telavancin Injection Telavancin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Topotecan Topotecan The risk or severity of adverse effects can be increased when Pemetrexed is combined with Topotecan.
Golimumab Injection Golimumab Injection The metabolism of Pemetrexed can be increased when combined with Golimumab.
Pazopanib Pazopanib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Pazopanib.
Asenapine Asenapine The metabolism of Asenapine can be decreased when combined with Pemetrexed.
Albendazole Albendazole The metabolism of Pemetrexed can be decreased when combined with Albendazole.
Denosumab Injection Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Pemetrexed.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Pemetrexed.
Tocilizumab Injection Tocilizumab Injection The metabolism of Pemetrexed can be increased when combined with Tocilizumab.
Dalfampridine Dalfampridine Dalfampridine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fingolimod Fingolimod Pemetrexed may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection Eribulin Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Cabazitaxel.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ipilimumab Injection Ipilimumab Injection Ipilimumab may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of adverse effects can be increased when Aldesleukin is combined with Pemetrexed.
Sipuleucel-T Injection Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Pemetrexed.
Terbutaline Injection Terbutaline Injection Terbutaline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Belimumab Injection Belimumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Belimumab.
Busulfan Injection Busulfan Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Busulfan.
Roflumilast Roflumilast Roflumilast may increase the immunosuppressive activities of Pemetrexed.
Cyclophosphamide Injection Cyclophosphamide Injection The risk or severity of adverse effects can be increased when Cyclophosphamide is combined with Pemetrexed.
Abiraterone Abiraterone The serum concentration of Pemetrexed can be increased when it is combined with Abiraterone.
Rivaroxaban Rivaroxaban Rivaroxaban may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ticagrelor Ticagrelor The risk or severity of bleeding can be increased when Ticagrelor is combined with Pemetrexed.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Brentuximab vedotin.
Ruxolitinib Ruxolitinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ruxolitinib.
Clobazam Clobazam Clobazam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Vemurafenib Vemurafenib The serum concentration of Pemetrexed can be increased when it is combined with Vemurafenib.
Belatacept Injection Belatacept Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Belatacept.
Basiliximab Injection Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Pemetrexed.
Deferiprone Deferiprone Deferiprone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Pemetrexed.
Melphalan Injection Melphalan Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Melphalan.
Naloxone Injection Naloxone Injection Naloxone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Eculizumab Injection Eculizumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Eculizumab.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Carfilzomib Injection Carfilzomib Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Carfilzomib.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Pemetrexed.
Enzalutamide Enzalutamide Enzalutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Mirabegron Mirabegron Mirabegron may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Bosutinib Bosutinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Bosutinib.
Corticotropin, Repository Injection Corticotropin, Repository Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Corticotropin.
Glucarpidase Glucarpidase The metabolism of Pemetrexed can be increased when combined with Glucarpidase.
Teriflunomide Teriflunomide The serum concentration of Pemetrexed can be decreased when it is combined with Teriflunomide.
Teduglutide Injection Teduglutide Injection Teduglutide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Pemetrexed.
Tofacitinib Tofacitinib Pemetrexed may increase the immunosuppressive activities of Tofacitinib.
Alogliptin Alogliptin Alogliptin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimethyl Fumarate Dimethyl Fumarate The risk or severity of adverse effects can be increased when Pemetrexed is combined with Dimethyl fumarate.
Ponatinib Ponatinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ponatinib.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Pemetrexed is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Trastuzumab emtansine.
Apixaban Apixaban The risk or severity of bleeding can be increased when Apixaban is combined with Pemetrexed.
Canagliflozin Canagliflozin Canagliflozin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib Dabrafenib The excretion of Pemetrexed can be decreased when combined with Dabrafenib.
Trametinib Trametinib Trametinib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dolutegravir Dolutegravir The excretion of Pemetrexed can be decreased when combined with Dolutegravir.
Levomilnacipran Levomilnacipran Levomilnacipran may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Vortioxetine Vortioxetine Vortioxetine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Pemetrexed.
Ibrutinib Ibrutinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ibrutinib.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Obinutuzumab.
Simeprevir Simeprevir The metabolism of Pemetrexed can be decreased when combined with Simeprevir.
Sofosbuvir Sofosbuvir Sofosbuvir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Pemetrexed can be decreased when combined with Dapagliflozin.
Apremilast Apremilast The metabolism of Pemetrexed can be increased when combined with Apremilast.
Droxidopa Droxidopa Droxidopa may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Siltuximab Injection Siltuximab Injection The metabolism of Pemetrexed can be increased when combined with Siltuximab.
Vedolizumab Injection Vedolizumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Vedolizumab.
Belinostat Injection Belinostat Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Belinostat.
Idelalisib Idelalisib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Idelalisib.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Vorapaxar Vorapaxar The risk or severity of bleeding can be increased when Vorapaxar is combined with Pemetrexed.
Edoxaban Edoxaban Edoxaban may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Peginterferon beta-1a.
Olaparib Olaparib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Olaparib.
Blinatumomab Injection Blinatumomab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Blinatumomab.
Methamphetamine Methamphetamine Metamfetamine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tasimelteon Tasimelteon Tasimelteon may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pirfenidone Pirfenidone The risk or severity of adverse effects can be increased when Pemetrexed is combined with Pirfenidone.
Secukinumab Injection Secukinumab Injection The metabolism of Pemetrexed can be increased when combined with Secukinumab.
Palbociclib Palbociclib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Palbociclib.
Insulin Human Inhalation Insulin Human Inhalation The metabolism of Pemetrexed can be increased when combined with Insulin human.
Lenvatinib Lenvatinib The excretion of Pemetrexed can be decreased when combined with Lenvatinib.
Panobinostat Panobinostat The risk or severity of adverse effects can be increased when Pemetrexed is combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection Haloperidol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Amiloride Amiloride Amiloride may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Macitentan may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Prednisolone Prednisolone The risk or severity of adverse effects can be increased when Pemetrexed is combined with Prednisolone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Procaine benzylpenicillin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The metabolism of Pemetrexed can be increased when combined with Insulin degludec.
Mepolizumab Injection Mepolizumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Mepolizumab.
Trabectedin Injection Trabectedin Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Trabectedin.
Osimertinib Osimertinib The serum concentration of Pemetrexed can be decreased when it is combined with Osimertinib.
Ixazomib Ixazomib Ixazomib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lesinurad Lesinurad Lesinurad may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Dexamethasone.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Pemetrexed.
Ixekizumab Injection Ixekizumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ixekizumab.
Brivaracetam Injection Brivaracetam Injection Brivaracetam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Obeticholic Acid Obeticholic Acid The metabolism of Pemetrexed can be decreased when combined with Obeticholic acid.
Furosemide Injection Furosemide Injection Furosemide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Rucaparib Rucaparib The excretion of Rucaparib can be decreased when combined with Pemetrexed.
Lixisenatide Injection Lixisenatide Injection Lixisenatide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Brodalumab Injection Brodalumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Brodalumab.
Doxepin (Insomnia) Doxepin (Insomnia) Pemetrexed may decrease the excretion rate of Doxepin which could result in a higher serum level.
Deutetrabenazine Deutetrabenazine Deutetrabenazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Valbenazine Valbenazine Valbenazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Deflazacort Deflazacort The risk or severity of adverse effects can be increased when Pemetrexed is combined with Deflazacort.
Safinamide Safinamide The metabolism of Pemetrexed can be decreased when combined with Safinamide.
Ocrelizumab Injection Ocrelizumab Injection Ocrelizumab may increase the immunosuppressive activities of Pemetrexed.
Naldemedine Naldemedine Naldemedine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sarilumab Injection Sarilumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Pemetrexed can be decreased when combined with Midostaurin.
Guselkumab Injection Guselkumab Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Guselkumab.
Enasidenib Enasidenib The excretion of Pemetrexed can be decreased when combined with Enasidenib.
Benznidazole Benznidazole Benznidazole may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Delafloxacin Delafloxacin Delafloxacin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Betrixaban Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Pemetrexed.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Pemetrexed.
Letermovir Letermovir The excretion of Pemetrexed can be decreased when combined with Letermovir.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Apalutamide Apalutamide Apalutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Penicillamine Penicillamine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Penicillamine.
Avatrombopag Avatrombopag The excretion of Pemetrexed can be decreased when combined with Avatrombopag.
Baricitinib Baricitinib The risk or severity of adverse effects can be increased when Pemetrexed is combined with Baricitinib.
Lofexidine Lofexidine Lofexidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Plazomicin Injection Plazomicin Injection Plazomicin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Binimetinib Binimetinib The metabolism of Binimetinib can be decreased when combined with Pemetrexed.
Ivosidenib Ivosidenib The excretion of Pemetrexed can be decreased when combined with Ivosidenib.
Cannabidiol Cannabidiol The metabolism of Pemetrexed can be decreased when combined with Cannabidiol.
Stiripentol Stiripentol Stiripentol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Methoxy Polyethylene Glycol-Epoetin Beta Injection Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pemetrexed.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Paclitaxel.
Rifamycin Rifamycin The metabolism of Pemetrexed can be decreased when combined with Rifamycin.
Prucalopride Prucalopride Prucalopride may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ravulizumab-cwvz Injection Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ravulizumab.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Pemetrexed can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Pemetrexed is combined with Siponimod.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Pemetrexed.
Esomeprazole Injection Esomeprazole Injection The excretion of Pemetrexed can be decreased when combined with Esomeprazole.
Risankizumab-rzaa Injection Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Risankizumab.
Cladribine Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Pemetrexed.
Solriamfetol Solriamfetol Solriamfetol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Triclabendazole Triclabendazole The metabolism of Pemetrexed can be decreased when combined with Triclabendazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Pemetrexed.
Pitolisant Pitolisant Pitolisant may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Pemetrexed can be increased when combined with Fosphenytoin.
Ozanimod Ozanimod The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ozanimod.
Selumetinib Selumetinib The metabolism of Selumetinib can be decreased when combined with Pemetrexed.
Capmatinib Capmatinib The metabolism of Pemetrexed can be decreased when combined with Capmatinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Pemetrexed can be decreased when it is combined with Satralizumab.
Cabotegravir Cabotegravir The excretion of Pemetrexed can be decreased when combined with Cabotegravir.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Viloxazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Theophylline Theophylline The metabolism of Pemetrexed can be decreased when combined with Theophylline.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Isotretinoin Isotretinoin Pemetrexed may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Hydroxyurea Hydroxyurea The risk or severity of adverse effects can be increased when Pemetrexed is combined with Hydroxyurea.
Floxuridine Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Pemetrexed.
Metaxalone Metaxalone Metaxalone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Methotrexate is combined with Pemetrexed.
Primidone Primidone The metabolism of Pemetrexed can be increased when combined with Primidone.
Chlorpromazine Chlorpromazine Chlorpromazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Diazepam Diazepam Diazepam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Oxazepam Oxazepam Oxazepam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Flurazepam Flurazepam Flurazepam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Clorazepate Clorazepate Clorazepic acid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lorazepam Lorazepam Lorazepam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Carmustine Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Pemetrexed.
Amantadine Amantadine Amantadine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Codeine Codeine Codeine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tranylcypromine Tranylcypromine The metabolism of Pemetrexed can be decreased when combined with Tranylcypromine.
Phenelzine Phenelzine Phenelzine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Procarbazine.
Tetracycline Tetracycline Tetracycline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Thioguanine Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Pemetrexed.
Minocycline Minocycline The excretion of Pemetrexed can be decreased when combined with Minocycline.
Trifluoperazine Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Pemetrexed.
Bleomycin Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Pemetrexed.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Methadone Methadone Methadone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Benztropine Benztropine Benzatropine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Maprotiline Maprotiline Maprotiline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Orphenadrine Orphenadrine The metabolism of Pemetrexed can be decreased when combined with Orphenadrine.
Perphenazine Perphenazine The metabolism of Perphenazine can be decreased when combined with Pemetrexed.
Azathioprine Azathioprine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Azathioprine.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lomustine Lomustine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Lomustine.
Doxorubicin Doxorubicin The risk or severity of adverse effects can be increased when Pemetrexed is combined with Doxorubicin.
Cytarabine Cytarabine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Cytarabine.
Mechlorethamine Mechlorethamine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Mechlorethamine.
Dactinomycin Dactinomycin The risk or severity of adverse effects can be increased when Pemetrexed is combined with Dactinomycin.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Carbamazepine is combined with Pemetrexed.
Methyldopa Methyldopa Methyldopa may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Clonidine Clonidine The metabolism of Pemetrexed can be decreased when combined with Clonidine.
Hydralazine Hydralazine Hydralazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Warfarin Warfarin Pemetrexed may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam Clonazepam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Promethazine Promethazine Promethazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Daunorubicin Daunorubicin The risk or severity of adverse effects can be increased when Pemetrexed is combined with Daunorubicin.
Nitrofurantoin Nitrofurantoin Nitrofurantoin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Griseofulvin Griseofulvin The metabolism of Pemetrexed can be increased when combined with Griseofulvin.
Digoxin Digoxin Digoxin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Quinine Quinine The metabolism of Pemetrexed can be decreased when combined with Quinine.
Triamterene Triamterene Triamterene may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Pemetrexed.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital Secobarbital may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Desipramine Desipramine Pemetrexed may decrease the excretion rate of Desipramine which could result in a higher serum level.
Amitriptyline Amitriptyline Amitriptyline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Imipramine Imipramine Imipramine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Probenecid Probenecid Probenecid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Quinidine Quinidine The metabolism of Pemetrexed can be decreased when combined with Quinidine.
Procainamide Procainamide Pemetrexed may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Isoniazid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Rifampin Rifampin The metabolism of Pemetrexed can be increased when combined with Rifampicin.
Disopyramide Disopyramide Disopyramide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Valproic Acid Valproic Acid The excretion of Pemetrexed can be decreased when combined with Valproic acid.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Pemetrexed.
Mitomycin Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Pemetrexed.
Butabarbital Butabarbital Butabarbital may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Methimazole Methimazole The risk or severity of adverse effects can be increased when Pemetrexed is combined with Methimazole.
Propylthiouracil Propylthiouracil The risk or severity of adverse effects can be increased when Propylthiouracil is combined with Pemetrexed.
Chlorpropamide Chlorpropamide Chlorpropamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tolbutamide Tolbutamide Tolbutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tolazamide Tolazamide Tolazamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dinoprostone Dinoprostone The excretion of Pemetrexed can be decreased when combined with Dinoprostone.
Cyclobenzaprine Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Pemetrexed.
Baclofen Baclofen Baclofen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Pemetrexed which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Mercaptopurine Mercaptopurine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Mercaptopurine.
Phytonadione Phytonadione Phylloquinone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nadolol Nadolol Nadolol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Allopurinol Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Pemetrexed.
Flavoxate Flavoxate Flavoxate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fluorouracil Injection Fluorouracil Injection The risk or severity of adverse effects can be increased when Fluorouracil is combined with Pemetrexed.
Colchicine Colchicine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Colchicine.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dacarbazine Dacarbazine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Dacarbazine.
Acetazolamide Acetazolamide The therapeutic efficacy of Pemetrexed can be increased when used in combination with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Bacillus Calmette-Guerin (BCG) Vaccine Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Pemetrexed.
Ketoconazole Ketoconazole The metabolism of Pemetrexed can be decreased when combined with Ketoconazole.
Pyrantel Pyrantel Pyrantel may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Thiotepa Injection Thiotepa Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Thiotepa.
Vincristine Injection Vincristine Injection The risk or severity of adverse effects can be increased when Vincristine is combined with Pemetrexed.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Pemetrexed.
Vinblastine Vinblastine The risk or severity of adverse effects can be increased when Vinblastine is combined with Pemetrexed.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Thiothixene Thiothixene The metabolism of Thiothixene can be decreased when combined with Pemetrexed.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Chlorambucil Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Pemetrexed.
Alprazolam Alprazolam Alprazolam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Temazepam Temazepam Temazepam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Triazolam Triazolam Triazolam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dicyclomine Dicyclomine Dicyclomine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Propantheline Propantheline Propantheline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nifedipine Nifedipine Nifedipine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Verapamil Verapamil Verapamil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pindolol Pindolol Pindolol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cisplatin Injection Cisplatin Injection The risk or severity of adverse effects can be increased when Cisplatin is combined with Pemetrexed.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Bumetanide Bumetanide Bumetanide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Streptozocin Streptozocin The risk or severity of adverse effects can be increased when Streptozocin is combined with Pemetrexed.
Etoposide Etoposide The risk or severity of adverse effects can be increased when Pemetrexed is combined with Etoposide.
Glipizide Glipizide Glipizide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Indapamide Indapamide Indapamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Amoxicillin Amoxicillin Amoxicillin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nafcillin Injection Nafcillin Injection The metabolism of Pemetrexed can be increased when combined with Nafcillin.
Oxacillin Injection Oxacillin Injection Oxacillin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pentoxifylline Pentoxifylline Pentoxifylline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Auranofin Auranofin Auranofin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Gemfibrozil Gemfibrozil Gemfibrozil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Guanabenz Guanabenz The metabolism of Pemetrexed can be decreased when combined with Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Pemetrexed.
Enalapril Enalapril The excretion of Pemetrexed can be decreased when combined with Enalapril.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Amiodarone Amiodarone The metabolism of Pemetrexed can be decreased when combined with Amiodarone.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Buspirone Buspirone Buspirone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ciprofloxacin Ciprofloxacin The metabolism of Pemetrexed can be decreased when combined with Ciprofloxacin.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fluoxetine Fluoxetine The metabolism of Pemetrexed can be decreased when combined with Fluoxetine.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Pemetrexed.
Clozapine Clozapine The risk or severity of neutropenia can be increased when Pemetrexed is combined with Clozapine.
Estazolam Estazolam Estazolam may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Idarubicin Idarubicin The risk or severity of adverse effects can be increased when Pemetrexed is combined with Idarubicin.
Ofloxacin Ofloxacin The metabolism of Pemetrexed can be decreased when combined with Ofloxacin.
Didanosine Didanosine Didanosine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fludarabine Injection Fludarabine Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection The risk or severity of adverse effects can be increased when Pentostatin is combined with Pemetrexed.
Etodolac Etodolac Etodolac may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pravastatin Pravastatin The excretion of Pemetrexed can be decreased when combined with Pravastatin.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Pemetrexed.
Teniposide Injection Teniposide Injection The risk or severity of adverse effects can be increased when Teniposide is combined with Pemetrexed.
Lisinopril Lisinopril Lisinopril may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Zolpidem Zolpidem The metabolism of Pemetrexed can be decreased when combined with Zolpidem.
Isradipine Isradipine Isradipine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Omeprazole Omeprazole The metabolism of Pemetrexed can be increased when combined with Omeprazole.
Venlafaxine Venlafaxine Venlafaxine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Fluvoxamine Fluvoxamine The metabolism of Pemetrexed can be decreased when combined with Fluvoxamine.
Nefazodone Nefazodone Nefazodone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lamotrigine Lamotrigine Lamotrigine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tramadol Tramadol Tramadol may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Vinorelbine Injection Vinorelbine Injection The risk or severity of adverse effects can be increased when Vinorelbine is combined with Pemetrexed.
Carboplatin Injection Carboplatin Injection The risk or severity of adverse effects can be increased when Carboplatin is combined with Pemetrexed.
Lansoprazole Lansoprazole The excretion of Pemetrexed can be decreased when combined with Lansoprazole.
Ifosfamide Injection Ifosfamide Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Ifosfamide.
Pegaspargase Injection Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Pemetrexed.
Bupropion Bupropion Bupropion may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Metformin Metformin Metformin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Pemetrexed.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lamivudine Lamivudine Lamivudine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Riluzole Riluzole The metabolism of Riluzole can be decreased when combined with Pemetrexed.
Acarbose Acarbose Acarbose may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection The risk or severity of adverse effects can be increased when Gemcitabine is combined with Pemetrexed.
Ritonavir Ritonavir The metabolism of Pemetrexed can be increased when combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The risk or severity of adverse effects can be increased when Pemetrexed is combined with Docetaxel.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Meropenem Injection Meropenem Injection Meropenem may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Clomipramine Clomipramine Pemetrexed may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Zafirlukast Zafirlukast The metabolism of Pemetrexed can be decreased when combined with Zafirlukast.
Fosfomycin Fosfomycin Fosfomycin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Mirtazapine Mirtazapine The metabolism of Pemetrexed can be decreased when combined with Mirtazapine.
Topiramate Topiramate Topiramate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Pemetrexed.
Insulin Lispro Injection Insulin Lispro Injection The metabolism of Pemetrexed can be increased when combined with Insulin lispro.
Pramipexole Pramipexole Pramipexole may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Pemetrexed.
Nilutamide Nilutamide Nilutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Selegiline Selegiline The metabolism of Pemetrexed can be decreased when combined with Selegiline.
Propafenone Propafenone The metabolism of Pemetrexed can be decreased when combined with Propafenone.
Tamsulosin Tamsulosin Tamsulosin may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Quetiapine Quetiapine Quetiapine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Pemetrexed.
Tolcapone Tolcapone Tolcapone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Citalopram Citalopram The metabolism of Pemetrexed can be decreased when combined with Citalopram.
Capecitabine Capecitabine The risk or severity of adverse effects can be increased when Pemetrexed is combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Pemetrexed can be decreased when combined with Efavirenz.
Abacavir Abacavir Abacavir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Trastuzumab Injection Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Pemetrexed.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Tolterodine Tolterodine Tolterodine may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Pemetrexed is combined with Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Nateglinide Nateglinide Nateglinide may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Rabeprazole Rabeprazole Rabeprazole may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Pemetrexed.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists