FDA-filed SPL labeling · retrieved through openFDA

Pemetrexed Injection

Pemetrexed Injection is a chemotherapy medicine used to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma.

Brand names AlimtaPemfexyPemrydi RtuAxtlePemetrexed disodium +1 more
Drug classes ⓘ Folate Analog Metabolic Inhibitor
Rx Form 1 Routes Intravenous · Intraventricular
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 33 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveDec 1, 2022
Clinical labels in scope ⓘ33
AvailabilityRx
Earliest approval/marketing year ⓘ2004
FDA-listed product records ⓘ186
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 17, 2026
⭐ Pemetrexed Injection at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Pemetrexed Injection is a chemotherapy used to treat non-squamous non-small cell lung cancer and malignant pleural mesothelioma, given by IV infusion every 3 weeks. Taking folic acid, vitamin B12, and a steroid as directed is essential to reduce serious side effects, especially low blood counts. Your care team will monitor your kidneys and blood counts closely throughout treatment to keep you as safe as possible.
How we write & review this content — our editorial policy →

📖 Pemetrexed Injection: Patient Information Guide

A plain-language walkthrough of Pemetrexed Injection — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Pemetrexed Injection is a chemotherapy used across several cancer diagnoses. Here is the full list of supported uses:

  • In combination with pembrolizumab and platinum chemotherapy, for the initial treatment of metastatic non-squamous non-small cell lung cancer (NSCLC) in patients with no EGFR or ALK genomic tumor mutations
  • In combination with cisplatin, for the initial treatment of locally advanced or metastatic non-squamous NSCLC
  • As a single agent for maintenance treatment of locally advanced or metastatic non-squamous NSCLC in patients whose disease has not progressed after four cycles of platinum-based first-line chemotherapy
  • As a single agent for the treatment of recurrent, metastatic non-squamous NSCLC after prior chemotherapy
  • In combination with cisplatin, for the initial treatment of unresectable malignant pleural mesothelioma in patients who are not candidates for curative surgery
  • Not indicated for squamous cell non-small cell lung cancer
⚙️How it works▾

Pemetrexed is a folate analog metabolic inhibitor — it mimics folate (a B vitamin) to get inside cancer cells, then blocks key enzymes those cells need to build DNA and RNA. Specifically, it inhibits enzymes called thymidylate synthase, dihydrofolate reductase, and GARFT, all of which are essential for making the nucleotides (building blocks) that dividing cells require. Once inside the cell, pemetrexed is converted into longer-lasting forms that remain active and continue blocking these enzymes, helping to stop cancer cells from replicating.

💊How it's taken▾

Pemetrexed Injection is given as an intravenous (IV) infusion — into a vein — by a healthcare professional, typically over about 10 minutes on Day 1 of a 21-day cycle. The exact number of cycles depends on which condition is being treated, the treatment combination used, and how well the patient tolerates the drug.

  • Before and during treatment, patients must take daily oral folic acid, receive intramuscular vitamin B12 injections every 3 cycles, and take dexamethasone (a steroid) around the time of each infusion
  • Kidney function is checked before each cycle — the drug cannot be given if kidney function falls below a certain threshold
  • Blood counts are monitored at the beginning and during each cycle; the next cycle may be delayed or the dose adjusted if counts are too low

Follow your oncology team's instructions exactly. Do not adjust vitamins, steroids, or timing on your own.

🤒Side effects — in detail▾

The most common side effects depend on how pemetrexed is given:

  • As a single agent: fatigue, nausea, and loss of appetite
  • With cisplatin: vomiting, low white blood cell counts (neutropenia), anemia, mouth and throat sores, low platelets, and constipation
  • With pembrolizumab and platinum chemotherapy: fatigue or weakness, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, shortness of breath, and fever
  • Lab abnormalities commonly seen include high blood sugar, elevated liver enzymes, low sodium, low phosphate, and low red/white blood cell and platelet counts

Seek immediate medical attention for signs of serious infection (fever, chills), unusual bleeding, severe shortness of breath, blistering skin, or significant changes in urination — these can signal rare but life-threatening reactions.

⚠️Warnings & precautions▾
  • Bone marrow suppression (myelosuppression): Pemetrexed can severely lower blood cell counts, raising the risk of serious infection, bleeding, and anemia. Taking folic acid and vitamin B12 as directed reduces this risk significantly. Blood counts are checked before every cycle.
  • Kidney failure: Pemetrexed can cause severe or even fatal kidney damage. Kidney function must be measured before each dose. The drug cannot be given if kidney function drops too low.
  • Serious skin reactions: Rare but life-threatening blistering or peeling skin reactions (including Stevens-Johnson Syndrome) can occur. Treatment must be permanently stopped if these develop.
  • Interstitial pneumonitis (lung inflammation): New or worsening cough, shortness of breath, or fever should be reported immediately. If confirmed, pemetrexed must be permanently discontinued.
  • Radiation recall: Pemetrexed can trigger inflammation or blistering in areas of the body that received radiation — even years earlier. Report any such reactions promptly.
  • Embryo-fetal toxicity: This drug can cause serious birth defects and fetal harm. Effective contraception is required during treatment and for several months after the last dose for both men and women.
🔀What it interacts with▾

Pemetrexed Injection can interact with certain drugs that affect how it is cleared from the body:

  • Ibuprofen: Blocks a kidney transporter (OAT3) that helps remove pemetrexed, raising its level in the blood by about 20% — avoid for 2 days before and after each treatment, especially if kidney function is already reduced
  • Other OAT3 inhibitors: Any drug that blocks the OAT3 transporter can similarly raise pemetrexed exposure and increase the risk of serious side effects — avoid when possible
  • NSAIDs (non-steroidal anti-inflammatory drugs) in general: Discuss all anti-inflammatory pain relievers with your care team before using them during treatment
  • Aspirin at low-to-moderate doses: Does not appear to affect pemetrexed blood levels at doses up to 325 mg every 6 hours
  • Cisplatin and carboplatin: Used together with pemetrexed in several regimens — neither drug significantly changes the other's blood levels, but both require careful monitoring

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Do not use pemetrexed if you have had a severe allergic reaction to it in the past — this is a contraindication
  • Tell your doctor if your kidney function is reduced — the drug cannot be used if creatinine clearance is below 45 mL/min, and closer monitoring is needed for mild to moderate impairment
  • Tell your doctor about all medicines you take, especially ibuprofen and other NSAIDs
  • If you are pregnant or may become pregnant, discuss the risks — this drug can cause serious birth defects
  • Women of childbearing age must use effective contraception during treatment and for 6 months after the last dose
  • Men with partners who could become pregnant must use effective contraception during treatment and for 3 months after the last dose
  • Do not breastfeed during treatment or for 1 week after the last dose
  • This drug may impair male fertility — it is not known if the effect is reversible
  • Safety and effectiveness in children have not been established
  • Folic acid, vitamin B12, and dexamethasone must be started before the first infusion and continued as directed — these are not optional
🚑If you take too much▾

There is no approved antidote for a pemetrexed overdose. Based on animal studies, leucovorin (a folate-related drug) may help reduce the toxic effects of too much pemetrexed, but this has not been confirmed in people. It is not known whether pemetrexed can be removed from the body by dialysis.

📡Pharmacodynamics — effects in the body▾

Pemetrexed works by disrupting the processes cancer cells use to replicate. In lab studies, it inhibited the growth of mesothelioma cancer cell lines and showed enhanced effects when combined with cisplatin. The depth of the drop in neutrophils (a type of white blood cell) during treatment is linked to how much pemetrexed is in the body, and taking folic acid and vitamin B12 helps limit how severe that drop becomes. Importantly, this effect on neutrophil counts does not worsen with repeated cycles of treatment.

🔬Pharmacokinetics — how your body processes it▾

After an IV infusion, pemetrexed distributes throughout the body and is about 81% bound to proteins in the blood. It is largely not broken down by the liver and is instead excreted mostly unchanged in the urine — 70 to 90% is recovered within the first 24 hours. The drug's half-life (the time it takes for the body to clear half of it) is about 3.5 hours in people with normal kidney function, but this increases as kidney function declines, meaning the drug stays in the body longer and reaches higher levels. Age and sex do not meaningfully affect how the body handles pemetrexed.

📦How to store it▾

Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) .

📄 Written from Pemetrexed Injection’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

4

Supplements & herbs that interact with Pemetrexed Injection

4 supplements and herbal products have documented interactions with Pemetrexed Injection in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

AFRICAN WILD POTATO Moderate Banderol Moderate CAFFEIC ACID Moderate QUERCETIN Moderate
Every supplement checked against Pemetrexed Injection — ranked by severity The full interaction hub: 4 moderate · every one linked to its full report. Check Pemetrexed Injection against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Pemetrexed Injection — the kind of thing our pharmacy team would talk through with you at the counter.

Why do I have to take vitamins and a steroid along with my chemo — are they really necessary? ▾
Yes, they are absolutely necessary and not optional. The folic acid and vitamin B12 help protect your bone marrow and gut lining from the most severe side effects of pemetrexed — clinical studies showed much higher rates of dangerous low blood counts and infections in patients who did not take them. The dexamethasone steroid helps prevent skin reactions. Think of these as part of the treatment itself, not just supplements. Make sure you start the folic acid at least a week before your first infusion and don't stop until three weeks after your last dose.
Can I take ibuprofen or Advil while I'm on this treatment? ▾
You need to be careful with ibuprofen. It can block one of the kidney transporters that your body uses to clear pemetrexed, which means pemetrexed can build up to higher levels and cause more side effects. If your kidney function is already somewhat reduced, this risk is even greater. In general, your care team will ask you to avoid ibuprofen for two days before and two days after each treatment. Always check with your oncology team before taking any over-the-counter pain or anti-inflammatory medicines.
What side effects should I just expect, and which ones mean I need to call someone right away? ▾
Feeling tired, nauseous, and having less appetite are common and expected — your team can help manage those. But some symptoms need immediate attention: a fever (which can signal a dangerous infection when white blood cells are low), unusual bleeding or bruising, new or worsening shortness of breath or cough, blistering or peeling skin, or significant changes in how much you're urinating. Don't wait to see if these get better on their own — call your oncology team or go to an emergency room if you experience them.
Is this drug safe to use if I'm thinking about having children someday? ▾
This is really important to discuss with your doctor before starting treatment. Pemetrexed can cause serious harm to a developing baby, so women need to use effective birth control during treatment and for 6 months after the last dose. Men need to use contraception during treatment and for 3 months after. There's also a possibility the drug could affect male fertility, and it's not yet known if that's reversible. If having children in the future is important to you, talk to your care team about options — like fertility preservation — before you begin.
My kidneys aren't in perfect shape. Does that affect my treatment? ▾
Yes, kidney function matters a lot with pemetrexed. The drug is cleared almost entirely through the kidneys, so if they're not working well, pemetrexed can build up to higher levels in your blood and cause more serious side effects. Your team will check your kidney function before every single cycle. If it drops below a certain level, your treatment will be paused. If you're also taking ibuprofen and have reduced kidney function, the risks are even higher — so be sure your team knows everything you're taking.
I had radiation treatment in the past. Is that something my oncology team should know about? ▾
Definitely tell your team about any radiation you've received — even if it was years ago. Pemetrexed can occasionally trigger something called radiation recall, where areas of your body that were previously treated with radiation become inflamed or even blister again. It's not common, but it's real. Your team will keep an eye out for it, and if it happens, they'll need to stop the pemetrexed permanently.
Is Pemetrexed Injection available over the counter? ▾
Pemetrexed Injection is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Pemetrexed Injection first available? ▾
Pemetrexed Injection has been available in the United States since at least 2004, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Pemetrexed Injection? ▾
Pemetrexed Injection is supplied by 31 manufacturers listed in the FDA NDC Directory, including BluePoint Laboratories, Meitheal Pharmaceuticals Inc., Hospira, Inc..

💬 Answers drafted from Pemetrexed Injection’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Pemetrexed Injection supplement interactions4 checked — ranked by severity 🌿Drug & Supplement CheckerPemetrexed Injection vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Pemetrexed Injection NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Pemetrexed Injection comes

Pemetrexed Injection is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Injection

By injection · Into a vein · Intraventricular
Brands Alimta Axtle Pemetrexed Dipotassium Pemetrexed disodium Pemfexy Pemrydi Rtu
How this form is used
What it may be used for
  • Used intravenously, in combination with pembrolizumab and platinum chemotherapy, for the initial treatment of metastatic non-squamous non-small cell lung cancer with no EGFR or ALK tumor mutations
  • Used intravenously, in combination with cisplatin, for the initial treatment of locally advanced or metastatic non-squamous non-small cell lung cancer
  • Used intravenously as a single agent for maintenance treatment of locally advanced or metastatic non-squamous non-small cell lung cancer after platinum-based chemotherapy
  • Used intravenously, in combination with cisplatin, for initial treatment of unresectable malignant pleural mesothelioma
Important instructions
  • Given as an intravenous infusion over approximately 10 minutes on Day 1 of each 21-day cycle
  • Folic acid must be taken by mouth once daily starting 7 days before the first infusion and continued until 21 days after the last dose
  • Vitamin B12 is injected into the muscle 1 week before the first infusion and then every 3 cycles — oral B12 cannot be substituted
  • Dexamethasone is taken by mouth twice daily for 3 days, beginning the day before each infusion, to reduce skin side effects
Available strengths 13 strengths
25 mg/mL 100 mg 100 mg/4 mL 100 mg/4.2 mL 100 mg/10 mL 100 mg/100 mg
Show 7 more strengths Show fewer strengths
500 mg/20 mL 500 mg/50 mL 750 mg/30 mL 850 mg/34 mL 1 g/40 mL 1000 mg/40 mL 1000 mg/100 mL
186 FDA-listed product records ⓘ

📊 Pemetrexed Injection across the U.S. market

How Pemetrexed Injection appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1
Dose forms ⓘ
31
Manufacturers
7
Brand names
186
FDA-listed product records ⓘ
2004
First marketed ⓘ
BluePoint Laboratories12%
Meitheal Pharmaceuticals Inc.11%
Hospira, Inc.8%
Fresenius Kabi USA, LLC6%
Accord Healthcare Inc.6%
Teva Pharmaceuticals, Inc.5%
Other makers53%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Pemetrexed Injection is used

A general measure of how commonly Pemetrexed Injection is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Pemetrexed Injection is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

8,046
Medicaid prescriptions filled (Q1–Q4 2025)
$10.7M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Pemetrexed Injection prescribed? Of the 1,594 medications we measure, Pemetrexed Injection ranks #970 by Medicaid prescriptions — more than 39% of them.

Where Pemetrexed Injection ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #970 of 1,594
#965 Varenicline Nasal Spra... 8,153 Rx #966 IncobotulinumtoxinA In... 8,147 Rx #967 Teriflunomide 8,104 Rx #968 Darolutamide 8,087 Rx #969 Aspirin, Butalbital, a... 8,077 Rx #970 Pemetrexed Injection 8,046 Rx #971 Treprostinil Injection 7,921 Rx #972 Nicotine Nasal Spray 7,853 Rx #973 Cyanocobalamin Nasal G... 7,830 Rx #974 Carfilzomib Injection 7,827 Rx #975 Brinzolamide Ophthalmi... 7,791 Rx

Utilization by Pemetrexed Injection product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 500 mg injection is the most-dispensed Pemetrexed Injection product — about 48% of these Medicaid prescriptions.

pemetrexed 500 MG Injection Most dispensed

3,864 Medicaid prescriptions (Q1–Q4 2025) 48% of Pemetrexed Injection prescriptions shown $3M gross reimbursement (before rebates) ≈ $777 per prescription (gross)

Summed across the 12 of 27 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1728072

pemetrexed 100 MG Injection

2,759 Medicaid prescriptions (Q1–Q4 2025) 34% of Pemetrexed Injection prescriptions shown $2.5M gross reimbursement (before rebates) ≈ $892 per prescription (gross)

Summed across the 10 of 28 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1728077

pemetrexed 25 MG/ML Injectable Solution

1,339 Medicaid prescriptions (Q1–Q4 2025) 17% of Pemetrexed Injection prescriptions shown $5.1M gross reimbursement (before rebates) ≈ $3,840 per prescription (gross)

Summed across the 1 of 3 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2590672

pemetrexed 1000 MG Injection

36 Medicaid prescriptions (Q1–Q4 2025) <1% of Pemetrexed Injection prescriptions shown $3,023 gross reimbursement (before rebates) ≈ $84 per prescription (gross)

Summed across the 1 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2601728

50 ML pemetrexed 10 MG/ML Injection

26 Medicaid prescriptions (Q1–Q4 2025) <1% of Pemetrexed Injection prescriptions shown $70,595 gross reimbursement (before rebates) ≈ $2,715 per prescription (gross)

Summed across the 1 of 2 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2637968

4 ML pemetrexed 25 MG/ML Injection

22 Medicaid prescriptions (Q1–Q4 2025) <1% of Pemetrexed Injection prescriptions shown $2,705 gross reimbursement (before rebates) ≈ $123 per prescription (gross)

Summed across the 1 of 6 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 2602366

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Pemetrexed Injection, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 26 of 77 listed Pemetrexed Injection NDCs with Medicaid activity.

🔍 Compare Pemetrexed Injection products

A representative set of FDA-listed product records for Pemetrexed Injection — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 186 of 186 products — FDA National Drug Code Directory. See every product, package size and price: browse all 186 Pemetrexed Injection NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Pemetrexed Injection RxCUI 68446 2 dose forms · 12 strengths
  1. Dose form (SCDF) Injectable Solution RxCUI 2590671 In current FDA listings
    Clinical drug / strength (SCD) 25 MG/ML RxCUI 2590672

Look up RxCUI 68446 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Alimta Pemfexy Pemrydi Rtu Axtle Pemetrexed disodium Pemetrexed Dipotassium

🏭 Manufacturers & labelers

BluePoint Laboratories 22 Meitheal Pharmaceuticals Inc. 20 Hospira, Inc. 14 Fresenius Kabi USA, LLC 12 Accord Healthcare Inc. 11 Teva Pharmaceuticals, Inc. 9 Apotex Corp 9 Amneal Pharmaceuticals LLC 9 Sandoz Inc. 9 Eli Lilly and Company 8 Eugia US LLC 6 Shilpa Medicare Limited 6 Baxter Healthcare Corporation 4 Avyxa Pharma, LLC 4 Athenex Pharmaceutical Division, LLC. 4 Waverley Pharma Inc 4 Ingenus Pharmaceuticals, LLC 4 Lilly France 4 Zydus Pharmaceuticals USA Inc. 3 Zydus Lifesciences Limited 3 Eagle Pharmaceuticals, Inc. 3 Dr. Reddys Laboratories Inc 3 Qilu Pharmaceutical Co., Ltd. 2 Sagent Pharmaceuticals 2

…and 7 more on the FDA NDC directory.

RxNorm drug class

Pemetrexed Injection belongs to the Folate Analog Metabolic Inhibitor class.

Pharmacologic class Folate Analog Metabolic Inhibitor
Drug family (ATC) Folic acid analogues
How it works Folic Acid Metabolism Inhibitors

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Dec 1, 2022
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Pemetrexed Injection.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Pemetrexed Injection after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
33
NDC products indexed
186
Distinct labelers/manufacturers represented
31
Linked representative label ⓘ
Teva Pharmaceuticals, Inc.
Linked label effective
Dec 1, 2022
Composite sections available
23
Linked SPL Set ID
8b660f68-b770-4e0a-b2f9-25e663deecc3
Linked SPL Document ID
21155bd2-118e-4ce6-adb8-dddc69ae34c7
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 33 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Teva Pharmaceuticals, Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.