Penbutolol

190 interactions 1 explained in plain English 279 cited references

Also sold as: Levatol®

About Penbutolol

Penbutolol is used to treat high blood pressure. Penbutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. Read the full Penbutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Clonidine Vilanterol Indacaterol Oral Inhalation Lacosamide Injection Ceritinib Olodaterol Oral Inhalation

37 Major 153 Moderate

All (190) Major (37) Moderate (153)

Moderate

Penbutolol Meclofenamate Meclodium® Reduced antihypertensive effect Details Penbutolol Mefenamic Acid Ponstel® Reduced antihypertensive effect Details Penbutolol Meloxicam Alloxate Reduced antihypertensive effect Details Penbutolol Meloxicam Injection Alloxate Reduced antihypertensive effect Details Penbutolol Metformin Fortamet® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Methimazole Felanorm Altered metabolism of the beta-adrenergic blocker Details Penbutolol Methyldopa Aldomet® Exaggerated hypertensive response, tachycardia, or arrhythmias during physiologic stress or exposure to exogenous catecholamines Details Penbutolol Miglitol Glyset® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Nabumetone Relafen Reduced antihypertensive effect Details Penbutolol Naproxen Aleve Reduced antihypertensive effect Details Penbutolol Nateglinide Starlix® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details Penbutolol Aceclofenac Reduced antihypertensive effect Details Penbutolol Acemetacin Reduced antihypertensive effect Details Penbutolol Acetyldigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Penbutolol Albiglutide Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Amtolmetin Guacil Reduced antihypertensive effect Details Penbutolol Asenapine Saphris An increased risk of hypotension Details Penbutolol Bromfenac Bromsite Reduced antihypertensive effect Details Penbutolol Bufexamac Reduced antihypertensive effect Details Penbutolol Bunazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Carbimazole Altered metabolism of the beta-adrenergic blocker Details Penbutolol Celecoxib Celebrex Reduced antihypertensive effect Details Penbutolol Chlorpropamide Diabinese® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Choline Salicylate Reduced antihypertensive effect Details Penbutolol Clonixin Reduced antihypertensive effect Details Penbutolol Deslanoside Increased risk of bradycardia and possible digitalis glycoside toxicity Details Penbutolol Dexibuprofen Reduced antihypertensive effect Details Penbutolol Dexketoprofen Reduced antihypertensive effect Details Penbutolol Diclofenac Aleve Arthritis Pain Reduced antihypertensive effect Details Penbutolol Diflunisal Dolobid Reduced antihypertensive effect Details Penbutolol Digitoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Penbutolol Dipyrone Reduced antihypertensive effect Details Penbutolol Droxicam Reduced antihypertensive effect Details Penbutolol Dulaglutide Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Etofenamate Reduced antihypertensive effect Details Penbutolol Etoricoxib Reduced antihypertensive effect Details Penbutolol Etrasimod Velsipity May increase the risk of transient decrease in heart rate Details Penbutolol Exenatide Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Felbinac Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.