Penbutolol

190 interactions 1 explained in plain English 279 cited references

Also sold as: Levatol®

About Penbutolol

Penbutolol is used to treat high blood pressure. Penbutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. Read the full Penbutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Clonidine Vilanterol Indacaterol Oral Inhalation Lacosamide Injection Ceritinib Olodaterol Oral Inhalation

37 Major 153 Moderate

All (190) Major (37) Moderate (153)

Moderate

Penbutolol Acarbose Prandase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Penbutolol Aspirin Acuprin® Reduced antihypertensive effect Details Penbutolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Penbutolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Penbutolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Penbutolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Penbutolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Penbutolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Penbutolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Penbutolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Etodolac Lodine Reduced antihypertensive effect Details Penbutolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Fenoprofen Fenopron Reduced antihypertensive effect Details Penbutolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Penbutolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Penbutolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Penbutolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Penbutolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Penbutolol Ibuprofen Addaprin Reduced antihypertensive effect Details Penbutolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Ketoprofen Actron® Reduced antihypertensive effect Details Penbutolol Ketorolac Acular Reduced antihypertensive effect Details Penbutolol Ketorolac Injection Acular Reduced antihypertensive effect Details Penbutolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Penbutolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Penbutolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Liraglutide Injection Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Lixisenatide Injection Adlyxin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.