Penbutolol

190 interactions 1 explained in plain English 279 cited references
Also sold as: Levatol®
About Penbutolol

Penbutolol is used to treat high blood pressure. Penbutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. Read the full Penbutolol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Penbutolol Albuterol Oral Inhalation Accuneb® Explained Reduced efficacy of albuterol Details Penbutolol Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Penbutolol Indacaterol Oral Inhalation Arcapta® Decreased efficacy of indacaterol Details Penbutolol Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Penbutolol Methylergonovine Methergine An increased risk of enhanced vasoconstrictive Details Penbutolol Olodaterol Oral Inhalation Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure Details Penbutolol Albuterol ProAir Reduced efficacy of albuterol Details Penbutolol Ceritinib Zykadia Increased risk of bradycardia Details Penbutolol Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Penbutolol Crizotinib Xalkori An increased risk of bradycardia Details Penbutolol Darunavir Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Penbutolol Diltiazem Cardizem An increased risk of hypotension, bradycardia and slow AV conduction Details Penbutolol Dronedarone Multaq Increased exposure to some beta blockers and increased incidence of bradycardia Details Penbutolol Epinephrine Antagonized cardio stimulating, bronchodilation effects of EPINEPHrine and an increased risk of hypertension Details Penbutolol Fenoldopam Exaggeration of hypotensive response Details Penbutolol Fexinidazole Increased risk of bradycardia Details Penbutolol Fingolimod Gilenya Severe bradycardia or heart block Details Penbutolol Formoterol Perforomist Reduced efficacy of formoterol or reduced efficacy of beta-adrenergic blocker Details Penbutolol Indacaterol Decreased efficacy of indacaterol Details Penbutolol Insulin Afrezza Increased or reduced blood glucose lowering effect of insulin and reduced symptoms of hypoglycemia Details Penbutolol Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia, which may sometimes be followed by hyperglycemia and an increased risk of blunted recognition o... Details Penbutolol Iobenguane I 131 Azedra Inaccurate dosimetry calculations or reduced efficacy Details Penbutolol Iohexol Lower threshold for contrast reactions, increased risk of more severe contrast reaction, reduced efficacy when treating hypersensi... Details Penbutolol Lacosamide Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Penbutolol Landiolol An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block Details Penbutolol Levalbuterol Xopenex Reduced efficacy of levalbuterol Details Penbutolol Melatonin An increased risk of suppression of endogenous melatonin levels Details Penbutolol Olodaterol Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure Details Penbutolol Oxymetazoline Afrin Increased blood pressure Details Penbutolol Phenelzine Nardil An increased risk of exaggerated hypotensive effect and an increased risk of bradycardia Details Penbutolol Ponesimod Ponvory An increased risk of severe bradycardia and heart block Details Penbutolol Rivastigmine Exelon Additive bradycardic effects Details Penbutolol Salmeterol Serevent Reduced efficacy of salmeterol Details Penbutolol Siponimod Mayzent An increased risk of severe bradycardia and heart block Details Penbutolol Terbutaline Brethine® Reduced efficacy of terbutaline Details Penbutolol Verapamil Calan An increased risk of hypotension, bradycardia and slow AV conduction Details Penbutolol Vilanterol Decreased efficacy of vilanterol Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.