Penbutolol

190 interactions 1 explained in plain English 279 cited references

Also sold as: Levatol®

About Penbutolol

Penbutolol is used to treat high blood pressure. Penbutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. Read the full Penbutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Clonidine Vilanterol Indacaterol Oral Inhalation Lacosamide Injection Ceritinib Olodaterol Oral Inhalation

37 Major 153 Moderate

All (190) Major (37) Moderate (153)

Moderate

Penbutolol Fepradinol Reduced antihypertensive effect Details Penbutolol Feprazone Reduced antihypertensive effect Details Penbutolol Floctafenine Reduced antihypertensive effect Details Penbutolol Flufenamic Acid Reduced antihypertensive effect Details Penbutolol Glucagon A transient increase in pulse and blood pressure Details Penbutolol Glyburide DiaBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Indomethacin Indocin Reduced antihypertensive effect Details Penbutolol Insulin Aspart, Recombinant Fiasp Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Degludec Tresiba Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Detemir Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Glargine, Recombinant Basaglar Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Glulisine Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Human Inhaled Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Human Isophane (Nph) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Human Regular Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Insulin Lispro, Recombinant Admelog Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Lidocaine Akten An increase in the volume of distribution and a prolongation of the elimination half-life of lidocaine Details Penbutolol Lidoflazine Hypotension, bradycardia, and AV conduction disturbances Details Penbutolol Liraglutide Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Lixisenatide Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Lornoxicam Reduced antihypertensive effect Details Penbutolol Loxoprofen Reduced antihypertensive effect Details Penbutolol Lumiracoxib Reduced antihypertensive effect Details Penbutolol Ma Huang Reduced hypotensive effect of beta-adrenergic blockers Details Penbutolol Methacholine Impaired reversal of methacholine-caused bronchoconstriction Details Penbutolol Metildigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Penbutolol Morniflumate Reduced antihypertensive effect Details Penbutolol Moxisylyte An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Moxonidine Rebound hypertension Details Penbutolol Nepafenac Ilevro Reduced antihypertensive effect Details Penbutolol Niflumic Acid Reduced antihypertensive effect Details Penbutolol Nimesulide Reduced antihypertensive effect Details Penbutolol Nimesulide Beta Cyclodextrin Reduced antihypertensive effect Details Penbutolol Oxaprozin Coxanto Reduced antihypertensive effect Details Penbutolol Oxyphenbutazone Reduced antihypertensive effect Details Penbutolol Paltusotine Palsonify An increased risk of PR interval prolongation Details Penbutolol Parecoxib Reduced antihypertensive effect Details Penbutolol Phenoxybenzamine Dibenzyline An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Phentolamine An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Phenylbutazone Equi-Phar Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.