Penbutolol

190 interactions 1 explained in plain English 279 cited references

Also sold as: Levatol®

About Penbutolol

Penbutolol is used to treat high blood pressure. Penbutolol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure. Read the full Penbutolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Clonidine Vilanterol Indacaterol Oral Inhalation Lacosamide Injection Ceritinib Olodaterol Oral Inhalation

37 Major 153 Moderate

All (190) Major (37) Moderate (153)

Moderate

Penbutolol Piketoprofen Reduced antihypertensive effect Details Penbutolol Pioglitazone Actos Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Piroxicam Feldene Reduced antihypertensive effect Details Penbutolol Pramlintide Symlin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Pranoprofen Reduced antihypertensive effect Details Penbutolol Prazosin Minipress An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Proglumetacin Reduced antihypertensive effect Details Penbutolol Propyphenazone Reduced antihypertensive effect Details Penbutolol Proquazone Reduced antihypertensive effect Details Penbutolol Repaglinide Prandin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Rofecoxib Reduced antihypertensive effect Details Penbutolol Rosiglitazone Avandia® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Salicylic Acid Reduced antihypertensive effect Details Penbutolol Salsalate Disalcid Reduced antihypertensive effect Details Penbutolol Saxagliptin Onglyza Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Sitagliptin Brynovin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Sodium Salicylate Reduced antihypertensive effect Details Penbutolol Sulindac Clinoril® Reduced antihypertensive effect Details Penbutolol Tamsulosin Flomax An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Tenoxicam Reduced antihypertensive effect Details Penbutolol Terazosin Hytrin® An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Tiaprofenic Acid Reduced antihypertensive effect Details Penbutolol Tolazamide Tolinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Tolbutamide Orinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Tolfenamic Acid Reduced antihypertensive effect Details Penbutolol Tolmetin Tolectin 600 Reduced antihypertensive effect Details Penbutolol Tranylcypromine Parnate An increased risk of more pronounced bradycardia and postural hypotension Details Penbutolol Trimazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Urapidil An exaggerated hypotensive response to the first dose of the alpha blocker Details Penbutolol Valdecoxib Reduced antihypertensive effect Details Penbutolol Vildagliptin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Penbutolol Yohimbine Reduced beta-adrenergic blocker effectiveness Details Penbutolol Zileuton Zyflo A significant increase in beta-adrenergic blockade Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.