Perazine

20 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Buprenorphine Morphine Injection Diazepam Rectal Nalbuphine Injection Fentanyl Transdermal Patch
19 Major 1 Moderate
All (20) Major (19) Moderate (1)

Major

Perazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Perazine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Perazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Perazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Perazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Perazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Perazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Perazine Diazepam Rectal Diastat Increased risk of CNS depression Details Perazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Perazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Perazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Perazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Perazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Perazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Perazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Perazine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Perazine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Perazine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Perazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Perazine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.