Phenelzine
54 interactions 7 explained in plain English
Also sold as:
Nardil
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Fentanyl Transdermal Patch
Morphine Injection
Granisetron Transdermal Patch
Dopamine
Droxidopa
Granisetron Injection
Contraindicated
Phenelzine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Phenelzine Amitriptyline Elavil Explained An increased risk of CNS depression, an increased risk of neurotoxicity, seizures, and an increased risk of serotonin syndrome (hy... Details Phenelzine Sertraline Explained An increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) or CNS toxicit... Details Phenelzine Albuterol Oral Inhalation Accuneb® Explained An increased risk of hypertensive crisis Details Phenelzine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Phenelzine Butorphanol Injection Butorphic An increased risk of serotonin syndrome Details Phenelzine Butorphanol Nasal Spray Stadol® NS An increased risk of serotonin syndrome Details Phenelzine Clonidine Transdermal Patch Catapres An increased risk of hypertensive crisis Details Phenelzine Deutetrabenazine Austedo Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Phenelzine Diethylpropion Tenuate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Phenelzine Dolasetron Anzemet An increased risk of serotonin syndrome Details Phenelzine Dolasetron Injection Anzemet An increased risk of serotonin syndrome Details Phenelzine Dopamine An increased risk of hypertensive crisis (headache, hyperpyrexia, hypertension) Details Phenelzine Droxidopa Northera An increased risk of hypertensive crisis Details Phenelzine Entacapone Comtan Decreased catecholamine metabolism and risk for hypertensive crisis Details Phenelzine Fentanyl Transdermal Patch Duragesic® An increased risk of serotonin syndrome Details Phenelzine Granisetron Transdermal Patch Sancuso An increased risk of serotonin syndrome Details Phenelzine Granisetron Injection Granisol An increased risk of serotonin syndrome Details Phenelzine Hydromorphone Injection Dilaudid An increased risk of serotonin syndrome Details Phenelzine Hydromorphone Rectal available generically An increased risk of serotonin syndrome Details Phenelzine Levodopa Oral Inhalation Inbrija An increased risk of hypertensive crisis Details Phenelzine Linezolid Injection Zyvox An increased risk of hypertensive crisis (headache, palpitation, neck stiffness) or seizure Details Phenelzine Lithium Carbonate Lithobid An increased risk of serotonin syndrome and an increased risk of malignant hyperpyrexia Details Phenelzine Maprotiline Ludiomil® An increased risk of severe or life threatening reactions, like neurotoxicity, seizures Details Phenelzine Methyldopa Aldomet® Hypertensive crisis (headache, palpitation, neck stiffness) Details Phenelzine Methylphenidate Adhansia XR® An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Phenelzine Methylphenidate Transdermal Patch Daytrana An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Phenelzine Morphine Injection Astramorph® PF Increased risk of the CNS and respiratory depressant effects of morphine and an increased risk of serotonin syndrome Details Phenelzine Nalbuphine Injection Nubain® An increased risk of serotonin syndrome Details Phenelzine Opicapone Ongentys Increased risk of arrhythmias, increased heart rate, and excessive changes in blood pressure Details Phenelzine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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