Phenindione

68 interactions 3 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Etodolac Epoprostenol Diclofenac Ophthalmic Bromfenac Ophthalmic Orlistat

1 Contraindicated 51 Major 15 Moderate 1 Minor

All (68) Contraindicated (1) Major (51) Moderate (15) Minor (1)

Contraindicated

Phenindione Defibrotide Injection Defitelio Increased risk of bleeding Details

Major

Phenindione Sertraline Explained An increased risk of bleeding Details Phenindione Amoxicillin Amoxi Drop Increased INR and increased risk of bleeding Details Phenindione Apixaban Eliquis Explained An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Phenindione Aspirin Acuprin® Increased risk of bleeding Details Phenindione Aspirin Rectal Aspirin Increased risk of bleeding Details Phenindione Betrixaban Bevyxxa® Increased risk of bleeding Details Phenindione Anagrelide Agrylin Increased risk of bleeding Details Phenindione Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Phenindione Capecitabine Xeloda Increased vitamin K antagonist exposure and an increased risk of bleeding Details Phenindione Clopidogrel Plavix Increased risk of bleeding Details Phenindione Dabigatran Pradaxa® An increased risk of bleeding Details Phenindione Dabigatran Etexilate An increased risk of bleeding Details Phenindione Dalteparin Injection Fragmin Increased risk of bleeding Details Phenindione Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Phenindione Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Phenindione Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Phenindione Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Phenindione Dipyridamole Permole® Increased risk of bleeding Details Phenindione Doxycycline Injection Acticlate An increased risk of bleeding Details Phenindione Edoxaban Savaysa Increased risk of bleeding Details Phenindione Enoxaparin Lovenox Increased risk of bleeding Details Phenindione Enoxaparin Injection Lovenox Increased risk of bleeding Details Phenindione Epoprostenol Flolan Increased risk of bleeding Details Phenindione Etodolac Lodine An increased risk of bleeding Details Phenindione Fenoprofen Fenopron An increased risk of bleeding Details Phenindione Fluorouracil Adrucil Increased vitamin K antagonist exposure and an increased risk of bleeding Details Phenindione Fluorouracil Injection Adrucil Increased vitamin K antagonist exposure and an increased risk of bleeding Details Phenindione Fluorouracil Topical Carac Increased vitamin K antagonist exposure and an increased risk of bleeding Details Phenindione Flurbiprofen Ansaid An increased risk of bleeding Details Phenindione Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Phenindione Ibuprofen Addaprin An increased risk of bleeding Details Phenindione Iloprost Aurlumyn Increased risk of bleeding Details Phenindione Ketoprofen Actron® An increased risk of bleeding Details Phenindione Ketorolac Acular An increased risk of bleeding Details Phenindione Ketorolac Injection Acular An increased risk of bleeding Details Phenindione Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Phenindione Ketorolac Ophthalmic Acular An increased risk of bleeding Details Phenindione Lecanemab-Irmb Injection Leqembi An increased risk of amyloid related imaging abnormalities (ARIA), or intracerebral hemorrhage Details Phenindione Meclofenamate Meclodium® An increased risk of bleeding Details

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