Phenylbutazone

102 interactions 5 explained in plain English

Also sold as: Equi-Phar Equizone Pributazone Vetribute

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Deuruxolitinib Ketorolac Ketorolac Ophthalmic Ketorolac Injection Pemetrexed Injection

5 Contraindicated 68 Major 29 Moderate

All (102) Contraindicated (5) Major (68) Moderate (29)

Moderate

Phenylbutazone Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Atenolol Tenormin Explained Reduced antihypertensive effect Details Phenylbutazone Acebutolol Sectral® Reduced antihypertensive effect Details Phenylbutazone Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Betaxolol Betoptic S Reduced antihypertensive effect Details Phenylbutazone Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Phenylbutazone Bisoprolol Zebeta® Reduced antihypertensive effect Details Phenylbutazone Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Cholestyramine Resin Locholest® Decreased phenylbutazone absorption Details Phenylbutazone Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Phenylbutazone Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Esmolol Brevibloc Reduced antihypertensive effect Details Phenylbutazone Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Labetalol Normodyne® Reduced antihypertensive effect Details Phenylbutazone Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Phenylbutazone Levofloxacin Levaquin An increased risk of seizures Details Phenylbutazone Levofloxacin Injection Levaquin An increased risk of seizures Details Phenylbutazone Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Phenylbutazone Nadolol Corgard Reduced antihypertensive effect Details Phenylbutazone Nebivolol Bystolic Reduced antihypertensive effect Details Phenylbutazone Ofloxacin Floxin® An increased risk of seizures Details Phenylbutazone Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Phenylbutazone Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Phenylbutazone Penbutolol Levatol® Reduced antihypertensive effect Details Phenylbutazone Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.