Phenylbutazone
102 interactions 5 explained in plain English
Also sold as:
Equi-Phar
Equizone
Pributazone
Vetribute
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketorolac Nasal Spray
Deuruxolitinib
Ketorolac
Ketorolac Ophthalmic
Ketorolac Injection
Pemetrexed Injection
Contraindicated
Phenylbutazone Deuruxolitinib Increased deuruxolitinib exposure and an increased risk of deuruxolitinib-related adverse effects such as thrombosis Details Phenylbutazone Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Phenylbutazone Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Phenylbutazone Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Phenylbutazone Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) DetailsMajor
Phenylbutazone Amitriptyline Elavil Explained An increased risk of bleeding Details Phenylbutazone Sertraline Explained An increased risk of bleeding Details Phenylbutazone Apixaban Eliquis Explained An increased risk of bleeding Details Phenylbutazone Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Phenylbutazone Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Phenylbutazone Betrixaban Bevyxxa® An increased risk of bleeding Details Phenylbutazone Anagrelide Agrylin An increased risk of bleeding Details Phenylbutazone Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Phenylbutazone Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Phenylbutazone Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Phenylbutazone Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Phenylbutazone Clopidogrel Plavix An increased risk of bleeding Details Phenylbutazone Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Phenylbutazone Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Phenylbutazone Dabigatran Pradaxa® An increased risk of bleeding Details Phenylbutazone Dabigatran Etexilate An increased risk of bleeding Details Phenylbutazone Dalteparin Injection Fragmin An increased risk of bleeding Details Phenylbutazone Deferiprone Ferriprox Decreased deferiprone clearance and increased deferiprone plasma concentrations Details Phenylbutazone Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Phenylbutazone Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Phenylbutazone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Phenylbutazone Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Phenylbutazone Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Phenylbutazone Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Phenylbutazone Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Phenylbutazone Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Phenylbutazone Dipyridamole Permole® An increased risk of bleeding Details Phenylbutazone Edoxaban Savaysa An increased risk of bleeding Details Phenylbutazone Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Phenylbutazone Enoxaparin Lovenox An increased risk of bleeding Details Phenylbutazone Enoxaparin Injection Lovenox An increased risk of bleeding Details Phenylbutazone Epoprostenol Flolan An increased risk of bleeding Details Phenylbutazone Erdafitinib Balversa Increased erdafitinib exposure Details Phenylbutazone Estradiol Delestrogen Reduced contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleeding and/or... Details Phenylbutazone Estradiol Topical Divigel Reduced contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleeding and/or... DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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