Piketoprofen

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Injection Ketorolac Pemetrexed Injection Edoxaban
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Piketoprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Piketoprofen Iloprost Aurlumyn An increased risk of bleeding Details Piketoprofen Ketoprofen Actron® Increased risk of bleeding Details Piketoprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Piketoprofen Meclofenamate Meclodium® Increased risk of bleeding Details Piketoprofen Mefenamic Acid Ponstel® Increased risk of bleeding Details Piketoprofen Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Piketoprofen Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Piketoprofen Melphalan Alkeran An increased risk of bleeding Details Piketoprofen Melphalan Injection Alkeran An increased risk of bleeding Details Piketoprofen Mesalamine Apriso Increased risk of bleeding Details Piketoprofen Mesalamine Rectal Canasa Increased risk of bleeding Details Piketoprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Piketoprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Piketoprofen Nabumetone Relafen Increased risk of bleeding Details Piketoprofen Naproxen Aleve Increased risk of bleeding Details Piketoprofen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.