Piketoprofen
91 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Ketorolac Ophthalmic
Ketorolac Nasal Spray
Ketorolac Injection
Ketorolac
Pemetrexed Injection
Edoxaban
Contraindicated
Piketoprofen Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Piketoprofen Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Piketoprofen Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Piketoprofen Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) DetailsMajor
Piketoprofen Amitriptyline Elavil Explained An increased risk of bleeding Details Piketoprofen Sertraline Explained An increased risk of bleeding Details Piketoprofen Apixaban Eliquis Explained An increased risk of bleeding Details Piketoprofen Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Piketoprofen Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Piketoprofen Betrixaban Bevyxxa® An increased risk of bleeding Details Piketoprofen Anagrelide Agrylin An increased risk of bleeding Details Piketoprofen Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Piketoprofen Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Clopidogrel Plavix An increased risk of bleeding Details Piketoprofen Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Piketoprofen Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Piketoprofen Dabigatran Pradaxa® An increased risk of bleeding Details Piketoprofen Dabigatran Etexilate An increased risk of bleeding Details Piketoprofen Dalteparin Injection Fragmin An increased risk of bleeding Details Piketoprofen Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Piketoprofen Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Piketoprofen Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Piketoprofen Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Piketoprofen Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Piketoprofen Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Piketoprofen Dipyridamole Permole® An increased risk of bleeding Details Piketoprofen Edoxaban Savaysa An increased risk of bleeding Details Piketoprofen Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Piketoprofen Enoxaparin Lovenox An increased risk of bleeding Details Piketoprofen Enoxaparin Injection Lovenox An increased risk of bleeding Details Piketoprofen Epoprostenol Flolan An increased risk of bleeding Details Piketoprofen Etodolac Lodine Increased risk of bleeding Details Piketoprofen Fenoprofen Fenopron Increased risk of bleeding Details Piketoprofen Flurbiprofen Ansaid Increased risk of bleeding Details Piketoprofen Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Piketoprofen Fondaparinux Arixtra An increased risk of bleeding DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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