Piketoprofen

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Injection Ketorolac Pemetrexed Injection Edoxaban
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Moderate

Piketoprofen Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Atenolol Tenormin Explained Reduced antihypertensive effect Details Piketoprofen Acebutolol Sectral® Reduced antihypertensive effect Details Piketoprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Piketoprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Piketoprofen Bisoprolol Zebeta® Reduced antihypertensive effect Details Piketoprofen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Piketoprofen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Esmolol Brevibloc Reduced antihypertensive effect Details Piketoprofen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Labetalol Normodyne® Reduced antihypertensive effect Details Piketoprofen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Piketoprofen Levofloxacin Levaquin An increased risk of seizures Details Piketoprofen Levofloxacin Injection Levaquin An increased risk of seizures Details Piketoprofen Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Piketoprofen Nadolol Corgard Reduced antihypertensive effect Details Piketoprofen Nebivolol Bystolic Reduced antihypertensive effect Details Piketoprofen Ofloxacin Floxin® An increased risk of seizures Details Piketoprofen Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Piketoprofen Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Piketoprofen Penbutolol Levatol® Reduced antihypertensive effect Details Piketoprofen Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.