Piperaquine and Amlodipine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Piperaquine
No brand names on recordAmlodipine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of piperaquine and CYP3A4 substrates
Interaction Deep Dive
The concomitant use of piperaquine (a CYP3A4 substrate) with a CYP3A4 inhibitor may increase the exposure of piperaquine and the risk for QT prolongation. If concomitant use is required, ECG monitoring should be considered. Additionally, concurrent administration of piperaquine (a CYP3A4 inhibitor) and a CYP3A4 substrate may increase the exposure of the CYP3A4 substrate. Due to the long half-life of piperaquine, caution is advised when administering CYP3A4 inhibitors or a CYP3A4 substrate for up to 3 months after discontinuation of piperaquine therapy1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of piperaquine; inhibition of CYP3A4-mediated metabolism of this drug by piperaquine
Common questions
Can I take Piperaquine and Amlodipine together?
Increased exposure of piperaquine and CYP3A4 substrates Always confirm with your pharmacist or prescriber before making any change.
How serious is the Piperaquine and Amlodipine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Piperaquine or Amlodipine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: Eurartesim oral film-coated tablets, piperaquine tetraphosphate dihydroartemisinin oral film-coated tablets. Sigma-Tau Industrie Farmaceutiche Riunite S.p.A (per EMA), Rome, Italy, 2012.
Keep reading about Piperaquine
Keep reading about Amlodipine
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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