Piperaquine

91 interactions 6 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Granisetron Transdermal Patch Histrelin Implant Octreotide Moxifloxacin Lenvatinib Inotuzumab Ozogamicin Injection

63 Contraindicated 15 Major 13 Moderate

All (91) Contraindicated (63) Major (15) Moderate (13)

Contraindicated

Piperaquine Amitriptyline Elavil Explained Increased exposure of CYP2C19 substrates and increased risk of QT interval prolongation Details Piperaquine Sertraline Explained An increased risk of QT interval prolongation Details Piperaquine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Piperaquine Relugolix Orgovyx Explained An increased risk of QT interval prolongation Details Piperaquine Amisulpride Injection Barhemsys An increased risk of QT interval prolongation Details Piperaquine Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Piperaquine Aripiprazole Injection Abilify Increased exposure of CYP3A4 substrates and an increased risk of QT interval prolongation Details Piperaquine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Piperaquine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Piperaquine Azithromycin AzaSite An increased risk of QT interval prolongation Details Piperaquine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Piperaquine Anagrelide Agrylin An increased risk of QT interval prolongation Details Piperaquine Bedaquiline Sirturo An increased risk of QT interval prolongation Details Piperaquine Chloroquine Aralen® An increased risk of QT interval prolongation Details Piperaquine Dasatinib Phyrago Increased exposure of CYP3A4 substrates and an increased risk of QT interval prolongation Details Piperaquine Degarelix Injection Firmagon An increased risk of QT interval prolongation Details Piperaquine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Piperaquine Disopyramide Norpace An increased risk of QT interval prolongation Details Piperaquine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Piperaquine Dolasetron Anzemet An increased risk of QT interval prolongation Details Piperaquine Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Piperaquine Encorafenib Braftovi An increased risk of QT interval prolongation Details Piperaquine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Piperaquine Eribulin Injection Halaven An increased risk of QT interval prolongation Details Piperaquine Famotidine Calmicid An increased risk of QT interval prolongation Details Piperaquine Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Piperaquine Felbamate Felbatol An increased risk of QT interval prolongation Details Piperaquine Flecainide Tambocor® An increased risk of QT interval prolongation Details Piperaquine Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Piperaquine Fostemsavir Rukobia An increased risk of QT interval prolongation Details Piperaquine Galantamine Razadyne An increased risk of QT interval prolongation Details Piperaquine Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Piperaquine Gemifloxacin Factive An increased risk of QT interval prolongation Details Piperaquine Glasdegib Daurismo An increased risk of QT interval prolongation Details Piperaquine Goserelin Implant Zoladex An increased risk of QT interval prolongation Details Piperaquine Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Piperaquine Granisetron Injection Granisol An increased risk of QT interval prolongation Details Piperaquine Histrelin Implant Supprelin An increased risk of QT interval prolongation Details Piperaquine Hydroxychloroquine Plaquenil An increased risk of QT interval prolongation Details Piperaquine Inotuzumab Ozogamicin Injection Besponsa An increased risk of QT interval prolongation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.