Piperaquine

91 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Granisetron Transdermal Patch Histrelin Implant Octreotide Moxifloxacin Lenvatinib Inotuzumab Ozogamicin Injection
63 Contraindicated 15 Major 13 Moderate
All (91) Contraindicated (63) Major (15) Moderate (13)

Major

Piperaquine Bicalutamide Casodex Increased exposure of piperaquine Details Piperaquine Atorvastatin Atorvaliq Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Abiraterone Abirtega Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Amlodipine Amvaz® Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Cyclosporine Injection Atopica Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Cyclosporine Ophthalmic Cequa Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Dexamethasone Injection Decadron Decreased exposure of piperaquine and increased exposure of CYP3A4 substrates Details Piperaquine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased exposure of piperaquine and increased exposure of CYP3A4 substrates Details Piperaquine Miconazole Buccal Oravig Increased exposure of piperaquine Details Piperaquine Miconazole Topical Aloe Vesta Antifungal Increased exposure of piperaquine Details Piperaquine Miconazole Vaginal Lagicam Increased exposure of piperaquine Details Piperaquine Miconazole Aloe Vesta Antifungal Increased exposure of piperaquine Details Piperaquine Nafcillin Injection Unipen® Injection Reduced piperaquine exposure Details Piperaquine Nevirapine Viramune Reduced piperaquine exposure Details Piperaquine Ospemifene Osphena Increased exposure of piperaquine and CYP3A4 substrates Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.