Piperaquine

91 interactions 6 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Granisetron Transdermal Patch Histrelin Implant Octreotide Moxifloxacin Lenvatinib Inotuzumab Ozogamicin Injection

63 Contraindicated 15 Major 13 Moderate

All (91) Contraindicated (63) Major (15) Moderate (13)

Contraindicated

Piperaquine Ivabradine Corlanor Increased exposure of CYP3A4 substrates and an increased risk of QT interval prolongation Details Piperaquine Ketoconazole Topical Extina® Foam Increased exposure of piperaquine and CYP3A4 substrates and increased risk of QT-interval prolongation Details Piperaquine Lefamulin Xenleta An increased risk of QT interval prolongation Details Piperaquine Lenvatinib Lenvima An increased risk of QT interval prolongation Details Piperaquine Levofloxacin Levaquin An increased risk of QT interval prolongation Details Piperaquine Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Piperaquine Loperamide Diamode An increased risk of QT interval prolongation Details Piperaquine Mefloquine Lariam® An increased risk of QT interval prolongation Details Piperaquine Metronidazole Flagyl An increased risk of QT interval prolongation Details Piperaquine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Piperaquine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Piperaquine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Piperaquine Moxifloxacin Avelox An increased risk of QT interval prolongation Details Piperaquine Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Piperaquine Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Piperaquine Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Piperaquine Octreotide Bynfezia An increased risk of QT interval prolongation Details Piperaquine Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Piperaquine Ofloxacin Floxin® An increased risk of QT interval prolongation Details Piperaquine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Piperaquine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Piperaquine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation Details Piperaquine Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation Details

Major

Piperaquine Bicalutamide Casodex Increased exposure of piperaquine Details Piperaquine Atorvastatin Atorvaliq Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Abiraterone Abirtega Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Amlodipine Amvaz® Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Cyclosporine Injection Atopica Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Cyclosporine Ophthalmic Cequa Increased exposure of piperaquine and CYP3A4 substrates Details Piperaquine Dexamethasone Injection Decadron Decreased exposure of piperaquine and increased exposure of CYP3A4 substrates Details Piperaquine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased exposure of piperaquine and increased exposure of CYP3A4 substrates Details Piperaquine Miconazole Buccal Oravig Increased exposure of piperaquine Details Piperaquine Miconazole Topical Aloe Vesta Antifungal Increased exposure of piperaquine Details Piperaquine Miconazole Vaginal Lagicam Increased exposure of piperaquine Details Piperaquine Miconazole Aloe Vesta Antifungal Increased exposure of piperaquine Details Piperaquine Nafcillin Injection Unipen® Injection Reduced piperaquine exposure Details Piperaquine Nevirapine Viramune Reduced piperaquine exposure Details Piperaquine Ospemifene Osphena Increased exposure of piperaquine and CYP3A4 substrates Details

Moderate

Piperaquine Acetaminophen And Codeine Capital® & Codeine Explained Reduced exposure of CYP2E1 substrates Details Piperaquine Omeprazole Gastrobim Explained Increased exposure of CYP2C19 substrates Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.