Piperaquine

Name: Piperaquine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

91 interactions 6 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Granisetron Transdermal Patch Histrelin Implant Octreotide Moxifloxacin Lenvatinib Inotuzumab Ozogamicin Injection

63 Contraindicated 15 Major 13 Moderate

All (91) Contraindicated (63) Major (15) Moderate (13)

Moderate

Piperaquine Acetaminophen Acephen Reduced exposure of CYP2E1 substrates Details Piperaquine Acetaminophen Injection Acephen Reduced exposure of CYP2E1 substrates Details Piperaquine Acetaminophen Rectal Acephen Reduced exposure of CYP2E1 substrates Details Piperaquine Cyclophosphamide Cytoxan® Increased exposure of CYP2C19 substrates Details Piperaquine Cyclophosphamide Injection Cytoxan® Injection Increased exposure of CYP2C19 substrates Details Piperaquine Diazepam Nasal Spray Valtoco Increased exposure of CYP2C19 substrates Details Piperaquine Diazepam Rectal Diastat Increased exposure of CYP2C19 substrates Details Piperaquine Esomeprazole Nexium Increased exposure of CYP2C19 substrates Details Piperaquine Esomeprazole Injection Nexium Increased exposure of CYP2C19 substrates Details Piperaquine Lansoprazole Prevacid Increased exposure of CYP2C19 substrates Details Piperaquine Lanthanum Fosrenol® Reduced bioavailability of antimalarials Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.