Piperine

14 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Relugolix Digoxin Finerenone Loperamide Meloxicam Meloxicam Injection
8 Major 6 Moderate
All (14) Major (8) Moderate (6)

Major

Piperine Relugolix Orgovyx Explained Increased relugolix exposure Details Piperine Digoxin Cardoxin® Increased digoxin exposure Details Piperine Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Piperine Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Piperine Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Piperine Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Piperine Methylergonovine Methergine Increased methylergonovine exposure Details Piperine Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Piperine Amoxicillin Amoxi Drop Increased bioavailability of amoxicillin Details Piperine Cefotaxime Injection Claforan Increased bioavailability of cefotaxime Details Piperine Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Piperine Dofetilide Tikosyn Increased dofetilide exposure Details Piperine Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Piperine Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.