Drug Interaction Report

Piracetam and Clopidogrel: Interaction Details

A pharmacist-reviewed analysis of the Piracetam and Clopidogrel interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Clopidogrel

Plavix Plavix®
+

Piracetam

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 17 documented Piracetam interactions, 17 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Increased risk of bleeding

Interaction Deep Dive

A dose-dependent reduction in platelet function was reported with increasing doses of piracetam. Coadministration of piracetam and acenocoumarol , an anticoagulant, resulted in significantly decreased platelet aggregation. Therefore, use caution with concomitant use of piracetam and anticoagulants or antiplatelet agents, including low-dose aspirin, as this may increase the risk of bleeding.12.

Why it happens (mechanism)

Additive anticoagulant effect

Literature reports

2 reports — tap to read

a) Coadministration of piracetam and acenocoumarol significantly decreased platelet aggregation, beta-thromboglobulin release, and levels of fibrinogen, von Willebrand factors, and whole blood and plasma viscosity when compared with acenocoumarol alone 12.

b) A dose-dependent reduction in platelet function was reported with increasing doses of piracetam up to 12 g. There was no significant change in platelet count; however, bleeding time was prolonged 12.

Common questions

Can I take Piracetam and Clopidogrel together?

Increased risk of bleeding Always confirm with your pharmacist or prescriber before making any change.

How serious is the Piracetam and Clopidogrel interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Piracetam or Clopidogrel need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: Nootropil oral tablets, piracetam oral tablets. UCB Pharma Ltd. (per MHRA), Berkshire, United Kingdom, 2015.
  2. Product Information: NOOTROPIL(R) intravenous injection, piracetam intravenous injection. UCB Pharma S.P.A. (per HSA Singapore), Pianezza (TO), Italy, 2013.
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Clopidogrel

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All Clopidogrel interactions (359) Clopidogrel drug information
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Piracetam

Keep reading about Piracetam

All Piracetam interactions (17)
Also serious with: Edoxaban Heparin Injection Aspirin Rectal Enoxaparin
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Clopidogrel + Activated Charcoal Danshen Grapefruit Piracetam St. John's Wort Acacia Rigidula Aconite Adrafinil + 301 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.