Piretanide

50 interactions 4 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naproxen Morphine Injection Buprenorphine Bromfenac Ophthalmic Etodolac Diclofenac Ophthalmic

34 Major 16 Moderate

All (50) Major (34) Moderate (16)

Major

Piretanide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Piretanide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Piretanide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Piretanide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Piretanide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Piretanide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Piretanide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Piretanide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Piretanide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Piretanide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Lithium Carbonate Lithobid An increased risk of lithium toxicity Details Piretanide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Piretanide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Piretanide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details

Moderate

Piretanide Lisinopril Prinivil Explained Postural hypotension (first dose) Details Piretanide Amikacin Injection Amikin® Ototoxicity Details Piretanide Amikacin Oral Inhalation Arikayce Ototoxicity Details Piretanide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Piretanide Benazepril Lotensin Postural hypotension (first dose) Details Piretanide Captopril Capoten® Postural hypotension (first dose) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.