Potassium Oxybate

25 interactions 2 explained in plain English

Also sold as: Xywav

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Diphenhydramine Topical Nalbuphine Injection Lacosamide Injection Fentanyl Transdermal Patch Butorphanol Injection

2 Contraindicated 22 Major 1 Moderate

All (25) Contraindicated (2) Major (22) Moderate (1)

Contraindicated

Potassium Oxybate Diphenhydramine Injection Banophen An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Diphenhydramine Topical Afterbite with Antihistamine An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details

Major

Potassium Oxybate Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Buprenorphine Belbuca Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Aripiprazole Injection Abilify An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Asenapine Transdermal Patch Secuado An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Butorphanol Injection Butorphic An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Butorphanol Nasal Spray Stadol® NS An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Cetirizine Injection Aller-Tec An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Cetirizine Ophthalmic Zerviate An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Diazepam Nasal Spray Valtoco An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Diazepam Rectal Diastat An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Esketamine Nasal Spray Spravato An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Fentanyl Transdermal Patch Duragesic® An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Hydromorphone Injection Dilaudid An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Hydromorphone Rectal available generically An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Lacosamide Injection Motpoly An increased risk of CNS depression Details Potassium Oxybate Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Potassium Oxybate Metoclopramide Injection Gimoti An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Metoclopramide Nasal Spray Gimoti An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Midazolam Nasal Spray Nayzilam An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Midazolam Injection Nayzilam An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Morphine Injection Astramorph® PF An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Potassium Oxybate Nalbuphine Injection Nubain® An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details

Moderate

Potassium Oxybate Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.