Pranoprofen

56 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Methotrexate Ibuprofen Methotrexate Injection Hydrocortisone Injection Cyclosporine Ophthalmic
33 Major 23 Moderate
All (56) Major (33) Moderate (23)

Moderate

Pranoprofen Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Atenolol Tenormin Explained Reduced antihypertensive effect Details Pranoprofen Acebutolol Sectral® Reduced antihypertensive effect Details Pranoprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Pranoprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Pranoprofen Bisoprolol Zebeta® Reduced antihypertensive effect Details Pranoprofen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Pranoprofen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Esmolol Brevibloc Reduced antihypertensive effect Details Pranoprofen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Labetalol Normodyne® Reduced antihypertensive effect Details Pranoprofen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Pranoprofen Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Nadolol Corgard Reduced antihypertensive effect Details Pranoprofen Nebivolol Bystolic Reduced antihypertensive effect Details Pranoprofen Penbutolol Levatol® Reduced antihypertensive effect Details Pranoprofen Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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