Pranoprofen
56 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Amitriptyline
Methotrexate
Ibuprofen
Methotrexate Injection
Hydrocortisone Injection
Cyclosporine Ophthalmic
Major
Pranoprofen Amitriptyline Elavil Explained An increased risk of bleeding Details Pranoprofen Sertraline Explained An increased risk of bleeding Details Pranoprofen Apixaban Eliquis Explained An increased risk of bleeding Details Pranoprofen Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Pranoprofen Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Pranoprofen Betrixaban Bevyxxa® An increased risk of bleeding Details Pranoprofen Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Pranoprofen Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Pranoprofen Dabigatran Pradaxa® An increased risk of bleeding Details Pranoprofen Dabigatran Etexilate An increased risk of bleeding Details Pranoprofen Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Pranoprofen Edoxaban Savaysa An increased risk of bleeding Details Pranoprofen Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Pranoprofen Fondaparinux Arixtra An increased risk of bleeding Details Pranoprofen Fondaparinux Injection Arixtra An increased risk of bleeding Details Pranoprofen Heparin An increased risk of bleeding Details Pranoprofen Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Pranoprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Pranoprofen Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Pranoprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Pranoprofen Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Pranoprofen Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Pranoprofen Melphalan Alkeran An increased risk of bleeding Details Pranoprofen Melphalan Injection Alkeran An increased risk of bleeding Details Pranoprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Pranoprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... DetailsModerate
Pranoprofen Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Atenolol Tenormin Explained Reduced antihypertensive effect Details Pranoprofen Acebutolol Sectral® Reduced antihypertensive effect Details Pranoprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Pranoprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Pranoprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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