Prazosin

16 interactions 1 explained in plain English
Also sold as: Minipress Minipress® Minipress® XL
About Prazosin

Prazosin is used alone or in combination with other medications to treat high blood pressure. Prazosin is in a class of medications called alpha-blockers. It works by relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a common condition and when not treated, can cause… Read the full Prazosin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Alfuzosin Melphalan Melphalan Injection
3 Major 13 Moderate
All (16) Major (3) Moderate (13)

Moderate

Prazosin Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Prazosin Atenolol Tenormin Explained An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Acebutolol Sectral® An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Avanafil Stendra Increased risk of hypotension Details Prazosin Betaxolol Betoptic S An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Betaxolol Ophthalmic Betoptic® An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Bisoprolol Zebeta® An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Esmolol Brevibloc An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Labetalol Normodyne® An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Levobunolol Ophthalmic AKBeta® An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Nadolol Corgard An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Nebivolol Bystolic An exaggerated hypotensive response to the first dose of the alpha blocker Details Prazosin Penbutolol Levatol® An exaggerated hypotensive response to the first dose of the alpha blocker Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.