Primaquine

Name: Primaquine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

2 interactions 1 explained in plain English

Also sold as: Primaryl®

About Primaquine

Primaquine is used alone or with another medication to treat malaria (a serious infection that is spread by mosquitoes in certain parts of the world and can cause death) and to prevent the disease from coming back in people that are infected with malaria. Primaquine is in a class of medications called antimalarials. It… Read the full Primaquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline

1 Major 1 Moderate

All (2) Major (1) Moderate (1)

Major

Primaquine Sertraline Explained Increased CYP2D6 substrate exposure Details

Moderate

Primaquine Lanthanum Fosrenol® Reduced bioavailability of antimalarials Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.