Proglumetacin

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ketorolac Ophthalmic Ketorolac Injection Pemetrexed Injection Edoxaban
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Proglumetacin Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Proglumetacin Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Proglumetacin Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Proglumetacin Iloprost Aurlumyn An increased risk of bleeding Details Proglumetacin Ketoprofen Actron® Increased risk of bleeding Details Proglumetacin Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Proglumetacin Meclofenamate Meclodium® Increased risk of bleeding Details Proglumetacin Mefenamic Acid Ponstel® Increased risk of bleeding Details Proglumetacin Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Proglumetacin Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Proglumetacin Melphalan Alkeran An increased risk of bleeding Details Proglumetacin Melphalan Injection Alkeran An increased risk of bleeding Details Proglumetacin Mesalamine Apriso Increased risk of bleeding Details Proglumetacin Mesalamine Rectal Canasa Increased risk of bleeding Details Proglumetacin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Proglumetacin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Proglumetacin Nabumetone Relafen Increased risk of bleeding Details Proglumetacin Naproxen Aleve Increased risk of bleeding Details Proglumetacin Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.