Propafenone

67 interactions 5 explained in plain English
Also sold as: Rythmol Rythmol® Rythmol® SR
About Propafenone

Propafenone is an antiarrhythmic medication used to treat irregular heartbeat and help maintain a normal heart rate. Read the full Propafenone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Propafenone Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Sertraline Explained Increased propafenone exposure and risk toxicity (cardiac arrhythmias) and an increased risk of QT interval prolongation Details Propafenone Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Propafenone Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Propafenone Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Propafenone Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Propafenone Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Asenapine Transdermal Patch Secuado Increased propafenone exposure, an increased asenapine exposure and an increased risk of QT interval prolongation Details Propafenone Azithromycin AzaSite An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Propafenone Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Propafenone Alfuzosin UroXatral An increased risk of QT interval prolongation Details Propafenone Anagrelide Agrylin Increased risk of QT interval prolongation Details Propafenone Bedaquiline Sirturo Increased risk of QT interval prolongation Details Propafenone Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Propafenone Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Propafenone Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Propafenone Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Propafenone Dasatinib Phyrago An increased risk of QT interval prolongation Details Propafenone Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Propafenone Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Propafenone Digoxin Cardoxin® Increased digoxin exposure Details Propafenone Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Propafenone Encorafenib Braftovi Increased risk of QT interval prolongation Details Propafenone Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Propafenone Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Propafenone Fostemsavir Rukobia Increased risk of torsade de pointes Details Propafenone Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation Details Propafenone Gemifloxacin Factive Increased risk of QT interval prolongation Details Propafenone Glasdegib Daurismo Increased risk of QT interval prolongation Details Propafenone Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Propafenone Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation Details Propafenone Granisetron Injection Granisol Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.