Propofol

30 interactions 2 explained in plain English
Also sold as: Diprivan Propoflo Propovan Propoven
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fentanyl Transdermal Patch Nifedipine Midazolam Nasal Spray Butorphanol Injection Butorphanol Nasal Spray Lacosamide Injection
26 Major 4 Moderate
All (30) Major (26) Moderate (4)

Major

Propofol Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Propofol Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Propofol Azithromycin AzaSite An increased risk of QT interval prolongation Details Propofol Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Propofol Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Propofol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Propofol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Propofol Diazepam Nasal Spray Valtoco Additive cardiorespiratory effects Details Propofol Diazepam Rectal Diastat Additive cardiorespiratory effects Details Propofol Esketamine Nasal Spray Spravato Increased risk of sedation Details Propofol Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Propofol Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Propofol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Propofol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Propofol Hydroxychloroquine Plaquenil An increased risk of seizures Details Propofol Lacosamide Injection Motpoly An increased risk of CNS depression Details Propofol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Propofol Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Propofol Methylergonovine Methergine Increased methylergonovine exposure Details Propofol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Propofol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Propofol Midazolam Nasal Spray Nayzilam Additive cardiorespiratory effects Details Propofol Midazolam Injection Nayzilam Additive cardiorespiratory effects Details Propofol Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Propofol Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Propofol Nifedipine Adalat® Increased NIFEdipine exposure Details

Moderate

Propofol Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Propofol Dofetilide Tikosyn Increased dofetilide exposure Details Propofol Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Propofol Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.