Propylthiouracil

Name: Propylthiouracil Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

4 interactions

Also sold as: Propycil

About Propylthiouracil

Propylthiouracil is an antithyroid agent used to treat hyperthyroidism, a condition where the thyroid produces too much hormone. Read the full Propylthiouracil drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Mercaptopurine Methotrexate Methotrexate Injection

4 Major

All (4) Major (4)

Major

Propylthiouracil Azathioprine Azasan An increased risk of hepatotoxicity Details Propylthiouracil Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Propylthiouracil Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Propylthiouracil Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.