Propyphenazone
91 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
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Major
Propyphenazone Fondaparinux Injection Arixtra An increased risk of bleeding Details Propyphenazone Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Propyphenazone Heparin An increased risk of bleeding Details Propyphenazone Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Propyphenazone Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Propyphenazone Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Propyphenazone Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Propyphenazone Iloprost Aurlumyn An increased risk of bleeding Details Propyphenazone Ketoprofen Actron® Increased risk of bleeding Details Propyphenazone Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Propyphenazone Meclofenamate Meclodium® Increased risk of bleeding Details Propyphenazone Mefenamic Acid Ponstel® Increased risk of bleeding Details Propyphenazone Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Propyphenazone Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Propyphenazone Melphalan Alkeran An increased risk of bleeding Details Propyphenazone Melphalan Injection Alkeran An increased risk of bleeding Details Propyphenazone Mesalamine Apriso Increased risk of bleeding Details Propyphenazone Mesalamine Rectal Canasa Increased risk of bleeding Details Propyphenazone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Propyphenazone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Propyphenazone Nabumetone Relafen Increased risk of bleeding Details Propyphenazone Naproxen Aleve Increased risk of bleeding Details Propyphenazone Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... DetailsModerate
Propyphenazone Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Atenolol Tenormin Explained Reduced antihypertensive effect Details Propyphenazone Acebutolol Sectral® Reduced antihypertensive effect Details Propyphenazone Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Betaxolol Betoptic S Reduced antihypertensive effect Details Propyphenazone Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Propyphenazone Bisoprolol Zebeta® Reduced antihypertensive effect Details Propyphenazone Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Propyphenazone Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Esmolol Brevibloc Reduced antihypertensive effect Details Propyphenazone Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Propyphenazone Labetalol Normodyne® Reduced antihypertensive effect Details Propyphenazone Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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